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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Western blotting results revealed an upregulation in Bax:Bcl‑2 ratio, confirming the pro‑apoptotic effect of kefir, and an increase in p53 independent‑p21 expression upon kefir treatment. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Local Over-Expression of VEGF-DDNDC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis
Published 2014“…Results At 4 weeks post-injection, Ad.VEGF-DΔNΔC treated UtAs showed significantly lesser vasoconstriction (Emax144.0 v/s 184.2, p = 0.002). …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…It can happen that due to gene mutations, as for example when cancer progresses, the gene expression network undergoes some amount of localized re-wiring. …”
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The Use of the Gene Expression Omnibus (GEO) Database to Study Gene Expression and Methylation Patterns in Cases of Preterm Birth and Associated Diseases
Published 2023“…Remaining genes after filtering were studied for function and potential relevance to causes of PTB and associated diseases.</p> <h3>Results</h3> <p>Of the 8 datasets, 3 displayed significant changes in expression patterns after application of the filtering criteria. …”
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The combinatory effects of diet and exercise on BDNF gene expression
Published 2017“…Results showed that high protein diets induced BDNF expression and that combining this diet with voluntary exercise had an additive effect on BDNF expression. …”
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Variational Auto Encoder Approach To Find Deferentially Expressed Genes
Published 2022“…The proposed method makes use of cluster distribution on every latent space and merged weights in the decoder to assign genes to a cluster. My results discovered new sets of genes that were not shown using state-of-the-art techniques and can properly rank the top genes based on their significance in making clustering.…”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Analysis of facial emotion expression in eating occasions using deep learning
Published 2023“…The emotion felt while eating has a significant impact on our lives and affects different health conditions such as obesity. …”
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The unified effect of data encoding, ansatz expressibility and entanglement on the trainability of HQNNs
Published 2023“…Our framework aims to empirically analyze the joint impact of these factors on the training landscape of HQNNs. Our results show that the occurrence of the BP problem in HQNNs is contingent upon the expressibility of the underlying ansatz and the type of the adopted data encoding technique. …”
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miRNA-dependent regulation of STIM1 expression in breast cancer
Published 2019“…In contrast, STIM1 expression in the more aggressive basal triple-negative MDA-MB-231 cell line is not significantly modulated by a single miRNA species but is rather upregulated due to inhibition of the miRNA machinery through downregulation of Ago2. …”
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Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells
Published 2011“…Daoy and D556 human medulloblastoma cells pre-treated for 1 h with 0.2 μM sunitinib demonstrated induction of PTEN expression and significant inhibition of PDGFR signaling activity and transactivation of EGFR, in a RAS-independent manner, in response to PDGF-BB stimulation. …”
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Cytosolic Phospholipase A2-Mediated ICAM-1 Expression Is Calcium Dependent
Published 2001“…Groups were compared using ANOVA with Scheffe's post hoc analysis; *P < 0.05 vs control, †P < 0.05 vs LPS and TNF-α was considered significant; N ≥ 4 all experimental groups. Results. …”
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Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential
Published 2024“…Results from the cardiac function analysis displayed that DEHP significantly affected the arterial pulse and linear velocity within the Posterior Cardinal Vein (PCV) of exposed fish. …”
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