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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Preoperative Bevacizumab Does Not Significantly Increase Postoperative Complication Rates in Patients Undergoing Hepatic Surgery for Colorectal Cancer Liver Metastases
Published 2008“…Patients and Methods Two subgroups of patients who received neoadjuvant CTX + BV (n = 81) or CTX alone (n = 44) were identified from a database of patients who underwent surgery for CRC liver metastases. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Risk factors for stoma outlet obstruction: systematic review and meta-analysis
Published 2025“…Although age was assessed as a potential risk factor, it did not show a statistically significant association with SOO (OR 1.69, 95% CI 0.44–6.54).…”
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Prevalence, Associated Risk Factors, and Adverse Cardiovascular Outcomes of Statins Discontinuation: A Systematic Review
Published 2024“…Five studies that reported the cardiovascular risk of statin discontinuation within the first year of initiation showed significantly increased risk of discontinuation, including all‐cause mortality (hazard ratio: 1.36–3.65).…”
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Prevalence and risk of cognitive impairment among patients with asthma: A systematic review and meta‐analysis
Published 2025“…This systematic review and meta‐analysis aimed to elucidate the prevalence and risk of cognitive impairment in individuals with asthma.…”
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Direct Oral Anticoagulants Compared to Warfarin in Patients with Intermediate‐ to High‐Risk Pulmonary Embolism: A Systematic Review and Meta‐Analysis
Published 2025“…Direct oral anticoagulants were associated with comparable recurrence and mortality rates versus warfarin (odds ratio [OR] 0.72, 95% confidence interval [CI] 0.15–3.43) and (OR 0.57, 95% CI 0.16–2.01), respectively. There was no significant difference in the safety outcomes (major and minor bleeding events), with a trend towards a decreased risk among direct oral anticoagulant treated cohorts (OR 0.3, 95% CI 0.08–1.1) and (OR 0.64, 95% CI 0.24–1.7), respectively.…”
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Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis
Published 2024“…This systematic review and meta-analysis aim to assess the incidence and risk factors of NIs in adult.</p><h3>Methods</h3><p dir="ltr">We searched PubMed, Scopus, Web of Science, and ProQuest databases up to 2022. …”
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Privacy Preserving Cancellable Template Generation for Crypto-Biometric Authentication System
Published 2025“…Integrating cryptographic techniques with biometric modality has presented a dual-layered security mechanism, significantly mitigating the risk of biometric data breaches. …”
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The Impact of Board Gender Diversity on European Firms’ Performance: The Moderating Role of Liquidity
Published 2024“…Furthermore, the findings indicated that leverage had a significant negative impact on profitability. Finally, both the size and GDP have a significant beneficial impact on profitability. …”