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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Learning-Based Spectrum Sensing and Access for Cognitive Radio Systems
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InCR: Inception and concatenation residual block-based deep learning network for damaged building detection using remote sensing images
Published 2023“…<p dir="ltr">In February 2023, Turkey experienced a series of earthquakes that caused significant damage to buildings and affected many people. …”
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How Dynamic Capabilities in Maintenance Enable Metal Plants in the UAE Via Big Data Analytic Capabilities Towards Digital Twins Adoption? A Mediation and Moderation Analysis
Published 2024“…Additionally, low DL significantly strengthens moderation effect in terms of positive relationship between BDAC and adoption of DTs. …”
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Driving simulation sickness and the sense of presence: Correlation and contributing factors
Published 2021“…Importantly, designing buildings that replicate a real-world environment could increase SP and decrease SS. …”
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On-demand mobile sensing framework for traffic monitoring. (c2017)
Published 2017“…When compared to the traditional continuous sensing, our proposed on-demand sensing approach provides comparable high traffic estimation accuracy while significantly reducing the resource consumption.This is achieved by selecting the smallest number of data collectors that can provided the best quality of sensed data, in order to maintain a good traffic estimation accuracy and an improved system performance (i.e., lower response time and network load). …”
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Recent Developments in Printing Flexible and Wearable Sensing Electronics for Healthcare Applications
Published 2019“…<div><p>Wearable biosensors attract significant interest for their capabilities in real-time monitoring of wearers’ health status, as well as the surrounding environment. …”
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A novel on-demand vehicular sensing framework for traffic condition monitoring
Published 2018“…When compared to the traditional continuous sensing, our proposed on-demand sensing approach provides comparable high traffic estimation accuracy while significantly reducing the resource consumption. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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