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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Evaluation of antibiotic prophylaxis and other factors affecting the incidence of surgical site infection in appendectomy at a tertiary medical center in Lebanon. (c2003)
Published 2003“…The most common regimen used preoperatively was amoxicillin/clavulanic acid while the triple regimen was the most frequently used postoperatively. 7%, of the study population, developed surgical site infection (SSI); all had emergency appendectomy, and 71% received inappropriate preoperative prophylaxis. …”
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Site-Adaptation of Modeled Solar Radiation Data: The SiteAdapt Procedure
Published 2020“…This work presents a procedure for improving the accuracy of modeled solar irradiance series through site-adaptation with coincident ground-based measurements relying on the use of a regression preprocessing followed by an empirical quantile mapping (eQM) correction. …”
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Willingness to pay for digital wellbeing features on social network sites: a study with Arab and European samples
Published 2024“…<p dir="ltr">In recent years, concerns over the potential negative impacts of social network sites (SNS) on users’ digital wellbeing are on the rise. …”
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Assessment of the use of dolomite for the recovery of ammonia from field landfill leachate. (c2019)
Published 2019“…However, using dolomite calcined at 950 °C with the same phosphate source showed a significant decrease in removal efficiency to 44%, while using dolomite calcined at 750 °C (under continuous CO2 injection) resulted in a removal efficiency of 37%. …”
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Identification of potential managed aquifer recharge sites in hyper-arid environment using GIS and analytical hierarchy process
Published 2025“…Most of the highly and moderately suitable regions are located in the northern central parts of the country where seasonal surplus treated wastewater and desalinated water may be used to recharge groundwater. Furthermore, MAR technology can also be used to tackle saltwater intrusion in the coastal areas by injecting seasonal surplus desalinated and treated wastewater. …”
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Seismic Site Response, Analysis and Characterization of Major Cities in UAE
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Genetic and heuristic algorithms for regrouping service sites. (c2000)
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Artisanal fishing of spiny lobsters with gillnets — A significant anthropic impact on tropical reef ecosystem
Published 2015“…The analysis of target species using nocturnal visual census demonstrated a significantly higher number of P. echinatus at the site where gillnet use was virtually absent within three sampled habitats, fringe, cave and soft bottom. …”
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Choice of specimen’s extraction site affects wound morbidity in laparoscopic colorectal cancer surgery
Published 2022“…The choice of incision for extraction site is an independent predicative factor for significantly higher IH and increased SSI rates.…”
