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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Causes of Delay in Construction Projects in Oil and Gas Construction Industry
Published 2017“…Issues related to client performance included bureaucracy and late honouring of certificates. Secondary causes such as rework, the rate of productivity, dispute management and delay analysis were also found to have great significance. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd...
Published 2021“…NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. …”
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Investigating the Quality Combined Effect of Root Cause Analysis (RCA) in Quality Management in Manufacturing Firms
Published 2024“…Implementing a 6KV surge protector for higher-wattage lights significantly reduced defect rates by 0.5%. This improvement led to decreased warranty claims, cost reductions, and enhanced product longevity, ultimately reinforcing the company's commitment to delivering high-quality products that exceed the customer's expectations. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Developing a Stochastic Model to Predict Cost Overrun due to the Causes of Projects Delay in Oil Fields Construction Industry
Published 2020“…However, most of the causes of cost overrun were found to follow the Log logistic distribution – a family of distribution associated with projects where the risk increases at the initial phase of the project and decreases later on. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019
Published 2023“…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …”
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YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm
Published 2025“…Accurately identifying small defects on PCB surfaces remains a considerable challenge, particularly under complex background conditions, due to the intricate and compact layout of the boards. …”
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Impacts of twenty years of experimental warming on soil carbon, nitrogen, moisture and soil mites across alpine/subarctic tundra communities
Published 2022“…A significant plot-scale impact on mites suggests that small-scale heterogeneity may be important for buffering mites from global warming. …”
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Visitors off the trail: Impacts on the dominant plant, bryophyte and lichen species in alpine heath vegetation in sub-arctic Sweden
Published 2021“…The results showed that proximity to the trail did not cause a decrease in the majority of dominant species, with none of the eight most dominant vascular plants showing any significant effects of proximity to the trail. …”
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
Published 2009“…These types of devices have been shown to significantly decrease VAD occlusion rates by 8.2%, when compared to a standard connector device (Jacobs et al., 2004). …”
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