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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Treating Cancers Using Nature’s Medicine: Significance and Challenges
Published 2021“…In recent decades, the emphasis on identifying therapeutic plant-based active principles led to significant advancements in the identification and use of natural compounds to treat various diseases (Figure 1) [2,3]. …”
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Reduced Voltage Stress and Spikes in Source Current of 7-Level Switched-Capacitor Based Multilevel Inverter
Published 2023“…The proposed converter can significantly suppress the spikes appearing in the source current by including a small value of inductance connected to the soft charging circuit. …”
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Power System Stability With High Penetration of Renewable Energy Sources: Challenges, Assessment, and Mitigation Strategies
Published 2025“…<p dir="ltr">The incorporation of renewable energy sources (RESs) into power systems has significantly increased in recent years due to growing environmental, economic, and energy security concerns, posing new challenges for power system stability. …”
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A comparative overview of wet and dry cooling systems for Rankine cycle based CSP plants
Published 2013“…Today, the combination of global warming and volatile conventional fuel prices are key factors in driving investment in electricity generation plants based on the concentrated solar power (CSP) technology. …”
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