A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …”

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. By elucidating a mechanistic basis for the increased affinity of the N501Y mutant S1-RBD for ACE2, we believe that the results presented here will aid in developing therapeutic strategies against SARS-CoV-2 including designing of therapeutic agents targeting the ACE2-S1-RBD interaction.…”

Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains by Riachi, Naji J.

“…Decreased striatal dopamine levels in these latter rat strains were associated with increased dopamine turnover. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... by Wesal Habbab (17346961)

“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”

The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations by Al Kaaby Al Zoaby, Hassan

“…With the use of variable coefficient across the mat foundation, a significant decrease in the steel reinforcement is witnessed and an optimized/ more adapted steel distribution is observed.…”
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Whole-Genome Molecular Characterization and Typing of Staphylococcus aureus Isolated from Lebanon by El Hassan, Sarah

“…SCCmec typing of MRSA revealed the prevalence the type IV, and the most common strain was MRSA ST80-t044-IV. The worldwide dissemination of the MRSA-ST80 clone decreased over the past few years, but it was still the most common strain in Lebanon. …”
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Disrupted harvests: how Ukraine – Russia war influences global food systems – a systematic review by Hamid El Bilali (15864930)

“…This systematic study delves into this intricate interaction, examining scholarly literature to determine the magnitude and complexities of the war’s impact on global agri-food systems. …”

Carbon Nanotube Effect on the Ductility, Flexural Strength, and Permeability of Concrete by Mohamed O. Mohsen (14590765)

“…In this research, the effect of CNT use on the flexural strength, strain capacity, permeability, and microstructure of concrete was investigated. …”

Aorta deformation linked to heart disease by Nature Research (16552612)

“…They found that the mechanics of the aorta were altered, with the pulsatile change in aortic diameter, distention and elasticity of the aortic walls being significantly decreased, and aortic stiffness significantly increased, in HCM patients compared to the controls. …”

Characterization of Dse1 a candida albicans cells wall protein. (c2009) by Daher, Jalil Y.

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Release of colloids in saturated porous media under transient hydro-chemical conditions: A pore-scale study by Safna Nishad (16932474)

“…<p dir="ltr">The deposition and consequent release of colloids pose a significant challenge to the environment, groundwater quality and human health. …”

DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation by Abdelilah Arredouani (10914455)

“…In co-immunoprecipitation assays, DNAJB3 interacts with both JNK1 and IKKβ kinases. However, the functional impact of such interaction on their activities has not been investigated. …”

Social Media Use and Body Checking Among Lebanese Adults by Korkomaz, Aya

“…However, self-esteem, gender, and the number of online friends and their interaction with them lost significance. Additionally, the most significant variable in explaining the variation in body checking was emotional eating. …”
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Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice by Zeeni, N.

“…When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. …”
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines by Ismail, Jana

“…The combination of CBD with either cisplatin or paclitaxel exhibited a significant antagonistic interaction against SK-OV-3 cell line when compared to individual treatment (CI > 1). …”
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Notch Sensitivity of Fiber Reinforced Composite by Elyoussef, Mostafa

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Why do some countries produce more capital intensive output than others? by Toukan, Amjad

“…In my game theoretic analysis I model the interaction between firms and corrupt government officials as a contest while allowing for international variability in the quality of governance. …”
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Investigating vulnerability for developing eating disorders in a multi-confessional population by Doumit, Rita

“…Affiliating as Christian was found to significantly decrease the vulnerability to developing an ED. …”
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Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul, Hamid E.

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Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels by Haya Al-Sulaiti (5449256)

“…<p dir="ltr">Nanoparticles (NP) have gained significant attention in biomedical research due to their unique properties and potential applications in drug delivery, imaging, and diagnostics. …”