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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Characterization and Modeling of Damage in Steel at Different Strain Rates
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Subclinical Myocardial Dysfunction Assessment Using Speckle Tracking Echocardiography in Patients With Psoriasis: A Pilot Meta‐Analysis
Published 2024“…Two‐dimensional speckle‐tracking echocardiography (2D‐STE) can detect both regional and global myocardial strain. Impairment of ventricular strain can assist in the early detection of myocardial dysfunction. …”
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Strain response of hot-mix asphalt overlays for bottom-up reflective cracking
Published 2017“…Finally, an extrapolation of the strain history curve for various pavement design parameters was used to estimate the number of cycles for bottom-up crack initiation.…”
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Effect of Strain Fields on Frequency Band Gaps of Periodic Lattice-Based Metamaterials
Published 2024“…Different strain levels are used to determine the sensitivity of frequency band gaps to stretching strains. …”
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Characterization of Failure Strain In Fiber Reinforced Composites: Under On-Axis and Off-Axis Loading
Published 2021“…However, composite materials are taking over traditional materials owing to their significant mechanical properties. Fiber-reinforced composites exhibit lower ductility and failure strain, resulting in brittle failure, limiting their application where high ductility is desired. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex
Published 2019“…The use of ruthenium complexes as chemotherapeutic agents has been recently explored as one of the alternatives to conventional treatments. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A Low-Cost Strain Gauge Displacement Sensor Fabricated via Shadow Mask Printing
Published 2019“…The fabricated sensor shows a comparable performance (with a gauge factor of ~17.6) to those fabricated using costly lithography or inkjet printing schemes, while with a significantly lower production cost.…”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Biodegradation of chlorpyrifos by bacterial strains isolated from Lebanese soil and its association with plant growth improvement
Published 2022“…The 16S rDNA gene sequencing identified the two efficient chlorpyrifos-degrading bacterial strains as Stenotrophomonas maltophilia (RS1) and Acinetobacter calcoaceticus (RS3), which significantly (p < 0.01) degraded 71.3% and 73.5% of chlorpyrifos in the liquid medium, respectively, compared to 80% degradation (p < 0.01) when cultured as a consortium within 48 h. …”
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