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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Friction Reduction in Elastohydrodynamic Contacts by Thin Layer Thermal Insulation
Published 2014“…In this work, it is shown that contrarily to common belief, the friction reduction stems mainly from a thermal phenomenon and not only a chemical/surface interaction one. It is shown that a few micrometer-thin DLC coating can significantly influence the thermal behavior in a lubricated mechanical system. …”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Effect of bioceramic powder abrasion on different implant surfaces
Published 2024“…A non‐uniform dispersion of the treatment on the surface layer was visible on all treated surfaces. …”
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Characteristics of aerosols and planetary boundary layer dynamics during biomass burning season
Published 2025“…The planetary boundary layer (PBL) height, measured with Ceilometer LIDAR, showed decreasing trend in height from October to December that support aerosol accumulation near the surface during the the month of November. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Adsorbed Water Promotes Chemically Active Environments on the Surface of Sodium Chloride
Published 2023“…Depth profiles reveal transformed layers and elemental ratios at the crystal surfaces. …”
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2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces
Published 2024“…In this work, we prepared a layer of 2D magnesium phosphate (MgPi) coating on the surface of titanium surfaces via the spin-coating technique. …”
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2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces
Published 2024“…In this work, we prepared a layer of 2D magnesium phosphate (MgPi) coating on the surface of titanium surfaces via the spin-coating technique. …”
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YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm
Published 2025“…<p dir="ltr">Surface defects in Printed Circuit Boards (PCBs), which arise during manufacturing, significantly impact product quality and directly influence equipment performance, stability and reliability. …”