Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy by Taki, Fatima

“…Inhibition of autophagy, using chloroquine, led to a significant decrease in cell cytotoxicity evident at 48 hours and up to 120 hours. …”
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Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death by Tohme, Sara

“…Our results demonstrate that the cytotoxicity of [HuArgI(Co)-PEG5000] in AML cells leads to the generation of reactive oxygen species (ROS). Scavenging ROS using NAC significantly decreases cell death but has minimal effect on autophagy activation, suggesting that the accumulation of ROS is downstream of autophagy activation but upstream of cell death. …”
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Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation by Zreik, Tony

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Preparation of albumin-targeted liposomes and the study of their release characteristics using ultrasound by Turki, Renad

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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …”

Applications of bioconvection for tiny particles due to two concentric cylinders when role of Lorentz force is significant by Lei Zhang (38117)

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”

L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

The effect of Inula Viscosa extract on inflammation, microbial growth, glycemia, and blood lipid profile. (c2005) by Zaza, Rola Mouin

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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. …”
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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling by Crystal M. Ghantous (14571292)

“…To mimic hypertension, the rat portal vein (RPV) was mechanically stretched, and the protective effects of APN on mechanical stretch-induced vascular remodeling and the molecular mechanisms involved were examined by using 10 <i>μ</i>g/ml APN. Mechanically stretching the RPV significantly decreased APN protein expression after 24 hours and APN mRNA expression in a time-dependent manner in VSMCs. …”

Nasturtium officinalis water extract. (c2009) by Fares, Najwan

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Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling by Khalifeh, Mohamad Rabieh

“…The reported results indicated that WTS promoted resilience to stress and rescued social avoidance in the used mice model. Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …”
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The Protective Effects of Daucus carota L. ssp. carota and Cannabis sativa L. Extracts against Cisplatin Induced Nephrotoxicity in Animal Models by Al Toufaily, Sahar

“…Serum creatinine and urea, proteinuria, and inflammatory markers were measured. All used doses of COE showed significant decrease in serum urea; however, a significant decrease in serum creatinine was observed only at 20 mg/kg COE. …”
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Anticancer Effects of Lebanese Cannabis Oil Against in vivo and in vitro Models of Squamous Cell Carcinoma by Azar Atallah, Shirine

“…Intraperitoneal treatment of mice with COE (10, 25 or 50 mg/kg; 9 weeks) showed a non-significant decrease in tumor volume with respect to control, without adverse effects on liver and kidney function. …”
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines by Ismail, Jana

“…It has been used to treat various ailments, including epilepsy, anxiety, psychosis, inflammation, and cancer. …”
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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy by Jia-Zhen Wu (6844793)

“…Cells were co-transfected with a C-terminal modified α-synuclein (SynT) and synphilin-1, and then treated with DHM (10 μM) and Sal B (50 μM) 16 hours after transfection; levels of α-synuclein aggregation decreased significantly (68% for DHM and 75% for Sal B). …”

The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000) by Jabre, Mazen Gerges

“…The management of this disease is symptomatic, mainly based on the use of levodopa. Due to the high incidence of adverse effects associated with its chronic use, alternative treatments based on the direct-acting dopamine agonists have been used. …”
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