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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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A Meta-Analysis to Gauge the Effectiveness of STEM Informal Project-Based Learning: Investigating the Potential Moderator Variables
Published 2023“…However, the participants’ educational level and study location (country) did not emerge as being significant. This study contributes to the bulk of literature that can help academicians to design, develop and implement effective STEM-based informal PjBL models, with special consideration for influential variables (teaching method, assessment method, grade, location, course duration, group size, and subject area).…”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A Multi-Feature Based Approach Incorporating Variable Thresholds for Detecting Price Spikes in the National Electricity Market of Australia
Published 2021“…In this paper, a multi-feature based approach with the incorporation of variable thresholds is developed to detect electricity price spikes in the national electricity market of Australia. …”
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Development of highly active Cu-based CO<sub>2</sub> hydrogenation catalysts by solution combustion synthesis (SCS): Effects of synthesis variables
Published 2022“…<p dir="ltr">This work investigates the effects of solution combustion synthesis (SCS) variables on the performance of copper-based catalysts for CO<sub>2</sub> hydrogenation to methanol. …”
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Modeling of photovoltaic soiling loss as a function of environmental variables
Published 2017“…Then, an ANN-based model was set up to simulate the relationship between daily ΔCI and environmental variables and compared with a linear regression model, both models using the same input variables, including present day and previous day environmental conditions, and cumulative exposure time. …”
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Variable Selection in Data Analysis: A Synthetic Data Toolkit
Published 2024“…Variable (feature) selection plays an important role in data analysis and mathematical modeling. …”
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
Published 2022“…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. …”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Computation of intermodulation distortion in RF MEMS variable capacitor circuits using moments
Published 2016“…As a result, the moments method becomes a general multi-domain simulation method for quantifying nonlinear intermodulation distortion, while presenting significant computational cost reduction over harmonic balance-based methods.…”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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