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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Stand Structure and Dynamics of the Naturally Managed Oak-Dominated Forests and Their Relation to Environmental Variables in Swat Hindu Kush Range of Pakistan
Published 2023“…In contrast, the higher-elevation stand structures were dominated by Q. semecarpifolia, having stand parameters in moderate measures, while those at intermediate elevations have lower stand parameters. The environmental variables were negatively correlated with the stand structures, i.e., elevation (r = −0.51), precipitation (r = −0.47), and relative humidity (r = −0.77), whereas soil nutrients such as Potassium concentration have a significant negative relation with stands structure (r = −0.66) indicating their vital role in sustaining the oak communities. …”
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Modeling of photovoltaic soiling loss as a function of environmental variables
Published 2017“…Strong interactions were observed among environmental variables PM10, relative humidity (RH) and wind speed (WS) regarding their effect on the daily ΔCI. …”
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A cafeteria diet modifies the response to chronic variable stress in rats
Published 2012“…In addition, there was a significant interaction between stress and diet on serum corticosterone levels, which manifest as an increase in corticosterone levels in stressed rats relative to non-stressed controls in the HC and HF groups but not in the CAF group. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Iron-related dietary pattern increases the risk of poor cognition
Published 2019“…We aimed to examine the association between iron-related dietary pattern (IDP) and cognitive function in Chinese adults. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Impact of COVID-19 on health-related quality of life (HRQOL) and functional status
Published 2024“…Secondary outcomes, PCFS and mMRC showed a significant improvement (Figure 2). We studied the effect of variables such as age, gender, severity of the disease, presence of comorbidities, obesity, vaccination status and need for ventilatory support on EQ5L, PCFS and mMRC. …”
