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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Life cycle assessment of spectra-managed greenhouses for sustainable agriculture
Published 2023“…This study aims to conduct a comprehensive comparative life cycle assessment of conventional and spectra-managed greenhouses specifically designed for hot and arid climates. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Life Cycle Assessment for Integration of Solid Oxide Fuel Cells into Gas Processing Operations
Published 2021“…<p dir="ltr">The oil and gas industry generates a significant amount of harmful greenhouse gases that cause irreversible environmental impact; this fact is exacerbated by the world’s utter dependence on fossil fuels as a primary energy source and low-efficiency oil and gas operation plants. …”
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Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study
Published 2024“…MethodsThe age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. …”
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A Feasibility Study for Solar Energy Generation Policy Mechanisms in The UAE
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How sustainable is liquefied natural gas supply chain? An integrated life cycle sustainability assessment model
Published 2022“…Integrating sustainability into the distribution network process is a significant problem for any industry hoping to prosper or survive in today's fast-paced environment. …”
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How sustainable is liquefied natural gas supply chain? An integrated life cycle sustainability assessment model
Published 2022“…<p>Integrating sustainability into the distribution network process is a significant problem for any industry hoping to prosper or survive in today's fast-paced environment. …”
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Purpose Establishing the reliability of a new method to check the mean retinal and choroidal reflectivity and using it to find retinal and choroid changes in amblyopia. …”
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A Novel Hybrid Life Cycle Assessment Approach to Air Emissions and Human Health Impacts of Liquefied Natural Gas Supply Chain
Published 2021“…Following the midpoint results, the social human health impact findings were calculated using ReCiPe 2016 characterization factors to quantify the daily loss of life associated with the LNG process chain. SRU and TGTU units have the most significant social human health impact, followed by LNG loading (export terminal) with about 7409.0 and 1203.9 (DALY/million Ton LNG produced annually), respectively. …”