Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros by Mesmar, J.

“…In addition, ZNE significantly decreased the migratory and invasive capacity of Capan-2 with a concomitant downregulation of integrin α2 and increased cell–cell aggregation. …”
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Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening by Shurbaji, Samar Haroon

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Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening. by Shurbaji, Samar

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NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs by Posadino, Anna Maria

“…Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. …”
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Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia by Kuttikrishnan S.

“…Sang-mediated apoptosis was found to be associated with the increased expression of proapoptotic bax with concomitant decrease of Bcl-2 expression leading to depolarization of mitochondria membrane resulting in loss of mitochondrial membrane potential (MMP). …”
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The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes by Posa, Aniko

“…We found that OPA caused a significant elevation in the concentrations of IL-6 and TNF-, increased MPO activity and decreased HO enzyme activity in the plasma. …”
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling by Ghantous, Crystal M.

“…Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production. …”
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EFFECT OF ENDOPLASMIC RETICULUM STRESS MEDIATED BY HYPERGLYCEMIA ON BARRIER FUNCTION IN RETINAL CELLS by Saif, Atiya Ramadan

“…Results: We found that hyperglycemia increases the cellular production of reactive oxygen species (ROS) and PBA decreasing it. Also the barrier quality of HRMEC was affected significantly with treatment of high glucose and improved with PBA. …”
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Understanding the mechanisms mediating cardio-renal benefit of empagliflozin in type 2 diabetes mellitus by Dimitrios, Patoulias

“…In a recently published, post-hoc analysis of the hallmark EMPA-REG OUTCOME trial, Kramer ¨ et al.1 assessed whether changes in cardiac and haemodynamic markers achieved with empagliflozin in subjects with type 2 diabetes mellitus (T2DM) may mediate its significant benefits across a number of surrogate cardiovascular and kidney outcomes. …”
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Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells by Posadino, Anna Maria

“…Treatment of PC3 cells with 30 and 100μg/ml PE significantly decreased cell viability and proliferation. …”
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Signaling pathways activated by PACAP in MCF-7 breast cancer cells by Zibara, Kazem

“…Furthermore, PACAP induced ROS through H₂O₂ production whereas pretreatment with NAC inhibitor decreased AKT and ERK phosphorylation, but not p38. …”
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Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties by Mesmar, Joelle

“…Non-cytotoxic concentrations of OSEE attenuated cell proliferation and induced G0/G1 cell cycle arrest, which was associated with phosphorylation of p38 MAPK, an increase in the levels of tumor suppressor protein p21, and a decrease of proliferation marker protein Ki67. Additionally, only higher concentrations of OSEE were able to attenuate inhibition of proliferation induced by the ROS scavenger N-acetyl cysteine (NAC), indicating that the anti-proliferative effects of OSEE could be ROS-dependent. …”
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Estimating the production and mortality of fine roots using minirhizotrons in a Pinus densiflora forest in Gwangneung, Korea by Han, Seung Hyun

“…Both FP and FM at the 0–10 cm depth were significantly higher than at 10–20 and 20–30 cm depths, and this resulted from the decrease in nutrient availability with increasing soil depth. …”
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Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath, Chethan

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DEVELOPMENT AND EVALUATION OF VIRTUAL REALITY EXERGAMES FOR UPPER LIMB AMPUTEE REHABILITATION by MAZHAR, NOAMAN

“…Upper limb amputees face significant challenges in adapting to prosthetic limbs, leading to suboptimal rehabilitation outcomes and decreased quality of life. …”
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Association between Insulin and Nitric Oxide in Human Retinal Microvascular Endothelial Cells in vitro by Rizk, Nasser Moustafa

“…This study demonstrated that hyperglycemia causes an increase in ROS/oxidative stress and apoptosis, while insulin promotes a significant decrease in ROS and apoptosis. eNOS mediated NO production increases with hyperglycemia but remarkably decreases with insulin treatment after 1 hour, 2 hours and 4 hours. …”
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ASSOCIATION BETWEEN INSULIN RESISTANCE AND NITRIC OXIDE IN HUMAN RETINAL MICROVASCULAR ENDOTHELIAL CELLS IN VITRO by Bushra, Sumbul

“…This study demonstrated that Hyperglycemia causes an increase in ROS/oxidative stress and apoptosis, while insulin promotes a significant decrease in ROS and apoptosis, eNOS mediated NO production increases with hyperglycemia but remarkably reduced with insulin treatment after 1hour, 2 hours and 4 hours. …”
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Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanis... by Anwar-Mohamed, Anwar

“…Upon knockdown of AhR and Nrf2 the MMA(V)-, DMA(V)-, and TMA(V)-mediated induction of both CYP1A1 and NQO1 proteins was significantly decreased. …”
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Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells by Ola, El Atab

“…Hyperglycemia lead to a significant increase in APN synthesis in VSMCs, mainly through caveolae, but this increase failed to provide vascular protection because of the decreased expression of APN receptors, especially AdipoR2, which was assessed by qPCR. …”
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Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis by Zakaria, Zain Zaki

“…This was accompanied by a moderate decrease in blood flow (20%), significantly higher decrease in general cardiac output (65%), and reduction in red blood cells count (50%). …”
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