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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…The goal of this study is to assess PDA close status by echo with this current regimen. We aim to find the success rates of indomethacin treatment for hsPDA following unsuccessful ibuprofen treatment. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Furthermore, results from time‑lapse motility movies, wound‑healing, and invasion assays showed no effect on the motility of colorectal as well as breast (MCF‑7 and MB‑MDA‑231) cancer cells upon kefir treatment. Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Inland Treatment of the Brine Generated from Reverse Osmosis Advanced Membrane Wastewater Treatment Plant Using Epuvalisation System
Published 2013“…Plant growth parameters (plant height, fresh and dry weight) showed no significant difference between fresh water and brine treatments. …”
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Intravitreal bevacizumab (Avastin) treatment of retinal angiomatous proliferation
Published 2008“…No significant side effects were observed. Conclusion: These short-term data suggest that bevacizumab is a viable treatment option for RAP in AMD. …”
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Recent advances in the treatment and outcome of locally advanced rectal cancer
Published 1999“…Objective To compare the outcomes of treatment of locally advanced rectal cancer of the early era (1975–1990) with those of the late era (1991–1997). …”
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Growth hormone treatment modulates active ghrelin levels in rats
Published 2014“…Results: In control groups, the highest active ghrelin concentration in pmol/g tissue was found in the stomach (15.5 ± 0.21) followed by the pancreas (1.96 ± 0.066) and the kidney (1.36 ± 0.037). Genotropin treatment caused a dose dependent decrease in active ghrelin concentration in stomach, kidney and pancreas with a concomitant increase in plasma, and reaching significance at 20 and 100 µg/rat/day doses. …”
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Metformin treatment inhibits motility and invasion of glioblastoma cancer cells
Published 2018“…The results show a significant decrease in the survival of SF268 cancer cells in response to treatment with metformin. …”
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Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity
Published 2023“…Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A Comprehensive Method of Ion Exchange Resins Regeneration and Its Optimization for Water Treatment
Published 2020“…Ion exchange membranes, specifically resin technology, lie at the heart of electrolytically conductive systems used in the treatment of wastewater. This chapter deals with ion exchange deionization and the effect of resin amount as well as the concentration of acid and base on the product conductivity. …”
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