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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Hydrodynamic Modelling of Sharjah lagoons (UAE) under Climate Changes
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Mitigating undercooling and overheating risk in existing desert schools under current and future climate using validated building simulation model
Published 2023“…In Palestine and neighboring regions, buildings are constructed without insulation and mechanical heating and cooling systems, leading to significant thermal discomfort for occupants. To address this issue, the paper in troduces a robust methodology that utilizes a validated building simulation model (BSM) created based on hourly indoor air temperature to assess indoor thermal comfort during winter and summer seasons under both current and future climates. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Reduced graphene aerogels as energy efficient selective oil sorbents
Published 2022“…The presence of H<sub>2</sub> significantly decreased the oxygen-containing functional groups in graphene aerogel. …”
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Self-reported awareness and attitude of cancer patients towards clinical nurse coordinators
Published 2017“…Methods: This is a cross sectional study that was conducted by distributing a self-reported and anonymous survey to 240 cancer patients visiting the center. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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An examination of how climate change could affect the future spread of Fusarium spp. around the world, using correlative models to model the changes
Published 2023“…Climate change is predicted to have a significant impact on the geographic distribution of various flora, fauna, and insect species by expanding, contracting, or shifting their suitable climate environment. …”
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Osteoporosis: An under-recognized public health problem
Published 2016“…This review aims to describe the underlying risk factors and provide guidance on changes in lifestyle for those at risk of developing osteoporosis. …”
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An examination of how climate change could affect the future spread of <i>Fusarium</i> spp. around the world, using correlative models to model the changes
Published 2023“…<p dir="ltr"><u>Climate change</u> is predicted to have a significant impact on the geographic distribution of various flora, fauna, and insect species by expanding, contracting, or shifting their suitable climate environment. …”
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The Global Economic crisis & organisation change: case studies in the UAE
Published 2009“…Much of the restructuring took place under the banner of increasing corporate financial performance, but a significant byproduct of the deep-rooted organisational change it involves is additional strain on the organisation’s relationship with employees, communities, taxpayers, governments & stakeholders (Heugens, P., Schenk, H. 2004). …”
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Changing management history, gender moderating pay to job satisfaction for IS users
Published 2014“…It also points to policy changes needed at the human resource management levels. …”
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Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients
Published 2021“…<h3>Background</h3><p dir="ltr">The management of chronic kidney disease (CKD) and its complications places a significant burden on patients, resulting in impairment of their health-related quality of life (HR-QOL). …”