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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Development And Significance Of Business Intelligence (BI) Platforms In Facilitating The Decision-Making Process In Dubai Government Entities
Published 2022“…Business Intelligence (BI) technologies provide a flexible platform for businesses to properly store, process, analyse and report data and processes. The use of BI technologies in handling critical data and facilitating data-driven decision making (DDD) has been realised by many literature studies. …”
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
Published 2022“…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. The LSB substitution method can minimize the error rate in embedding process and can achieve greater reliability in criteria, using novel algorithm based on value difference. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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Industrial Processes Performance Improvement using Six Sigma Principles and Tools
Published 2019“…In this project, TQM and Six Sigma DMAIC methodology were used to improve the process of paper bag making to make sure that the output of the manufacturing process meets the demands of customers. …”
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Nonlinear analysis of shell structures using image processing and machine learning
Published 2023“…<p dir="ltr">In this paper, we propose a novel approach to solve nonlinear stress analysis problems in shell structures using an image processing technique. In general, such problems in design optimisation or virtual reality applications must be solved repetitively in a short period using direct methods such as nonlinear finite element analysis. …”
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Novel method for water purification using activated adsorbents developed from sewage sludge
Published 2016“…Sewage sludge from Dubai was characterized using inductively coupled plasma and CHN elemental analysis. …”
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Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
Published 2011“…Leaders of schools in this region are in the process of identifying how to appropriately use PDPs as motivational tools for teachers to achieve improvement in learning.…”
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Toward an Accurate Spectrophotometric Evaluation of the Efficiencies of Photocatalysts in Processes Involving Their Separation Using Nylon Membranes
Published 2018“…This might lead to significant errors due to the adsorption of some pollutants within the structure of the membranes during the filtration process used to separate the solid particles of the photocatalysts to get a clear filtrate. …”
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Prediction the performance of multistage moving bed biological process using artificial neural network (ANN)
Published 2020“…<p dir="ltr">Complexity, uncertainty, and high dynamic nature of nutrient removal through biological processes (BPs) makes it difficult to model and control these processes, forcing designers to rely on approximations, probabilities, and assumptions. …”
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Estimating hydrogen absorption energy on different metal hydrides using Gaussian process regression approach
Published 2022“…<p dir="ltr">Hydrogen is a promising alternative energy source due to its significantly high energy density. Also, hydrogen can be transformed into electricity in energy systems such as fuel cells. …”
