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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression
Published 2020“…Epigenetic therapeutics, including DNA methyltransferase and histone deacetylase inhibitors, can be used to revert these epigenetic anomalies acquired during the progression of disease. These discoveries have established a promising therapeutic modality utilizing the combination of epigenetic and immunotherapeutic agents to restore the physiological epigenetic profile and to re-establish potent host immunosurveillance mechanisms. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Sample intelligence-based progressive hedging algorithms for the stochastic capacitated reliable facility location problem
Published 2024“…<p dir="ltr">Selecting facility locations requires significant investment to anticipate and prepare for disruptive events like earthquakes, floods, or labor strikes. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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DeepRaman: Implementing surface-enhanced Raman scattering together with cutting-edge machine learning for the differentiation and classification of bacterial endotoxins
Published 2025“…To classify raw SERS Raman spectra from biological materials, we propose DeepRaman, a new architecture inspired by the Progressive Fourier Transform and integrated with the scalogram transformation approach. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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LANGUAGE INSTRUCTORS’ PERCEPTIONS OF L2 SKILL ACQUISITION WITH ONLINE EDUCATIONAL TECHNOLOGY DURING COVID 19
Published 2021“…It provides a cross analysis of both qualitative and quantative data in order to assess the current changes taking place during Covid 19. This is significant, as teachers are the keys to learning. …”
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Palaeoenvironmental evolution, sea-level changes and Human occupation in Lemnos Island during last 6000 years (North Aegean Sea, Greece)
Published 2012“…Their age determination is in progress at the moment. On the basis of the mapped glacial forms, it was possible to reconstruct equilibrium lines for a sampling of several localities, which, along with the chronological classification, can shed light on the climatic change during past phases of glaciation. …”
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Lower limb EMG activation during reduced gravity running on an incline. Speed matters more than hills irrespective of indicated bodyweight
Published 2021“…<h3>Background</h3><p dir="ltr">Progressive loading of the lower limb muscles during running on a positive pressure or reduced gravity (Alter-G™) treadmill is suggested as a rehabilitation strategy after muscle and tendon injury but the influence of running up or downhill and at higher speeds is not known, nor are the interaction effects of speed, inclination, and indicated bodyweight.…”