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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Nomograph derivation for underwater sour gas releases in shallow waters based on computational fluid dynamics simulations
Published 2024“…<p dir="ltr">Ruptured <u>underwater pipelines</u> releasing sour gas (i.e., natural gas with high concentrations of H<sub>2</sub>S) pose significant threats to environmental safety due to their toxic and contaminative properties. …”
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Release of colloids in saturated porous media under transient hydro-chemical conditions: A pore-scale study
Published 2021“…<p dir="ltr">The deposition and consequent release of colloids pose a significant challenge to the environment, groundwater quality and human health. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Impacts of COVID-19 pandemic on environment, society, and food security
Published 2023“…However, its negative impacts are by far critical such as increased death rate, increased release of microcontaminants (pesticides, biocides, pharmaceuticals, surfactants, polycyclic aromatic hydrocarbons (PAHs), flame retardants, and heavy metals), increased biomedical waste generation due to excessive use of safety equipment and its disposal, and municipal solid waste generation. …”
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Impact of information availability on starvation mitigation and delay minimal delivery in ICRCNs
Published 2014“…In this case, it was shown in [1] that the downstream source SRU may suffer from a significant starvation problem. As such, a Markov decision process framework was established therein to identify a suitable Bulk Release Decision Policy (BRDP). …”
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Recovery of electro-mechanical properties inside self-healing composites through microencapsulation of carbon nanotubes
Published 2020“…A small amount of CNTs inside the microcapsules is found to have no significant impact on the thermal stability of the system, as determined by thermogravimetric analysis and differential scanning calorimetry. …”
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The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control
Published 2022“…<div><p>The nutritional state before and throughout pregnancy has a critical impact on the women's health and the baby's development and growth. …”
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The hazardous impacts of mining activities on population's health in Blue Nile State - Sudan
Published 2014“…<h3 dir="ltr">Background</h3><p dir="ltr">In recent decades the Ingessana Hills, namely the Bao and Jam areas located in the Southwest of the Blue Nile State in Sudan, have been very important areas due to their mining activities. By releasing bio-monitoring systems we can facilitate extensive evaluation of environmental hazards and their impact on human health.…”
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Socio‐economic impact of solar cooking technologies on community kitchens under different climate conditions: A review
Published 2024“…Moreover, the payback period ranges from 3 to 6 years, contingent on the technology's cost, climatic conditions, and available subsidies. Consequently, significant positive impacts on society, the economy, and the environment are observed when traditional cooking devices are replaced by solar cooking devices. …”
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The impact of taxation, technological innovation and trade openness on renewable energy investment: Evidence from the top renewable energy producing countries
Published 2024“…Conversely, innovation and trade openness exhibit a positive and significant influence on clean energy investment. Regarding the moderating influence of taxation, the results revealed that tax revenues depress the positive impact exerted by technological innovation and international trade. …”
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