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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Formation of Trihalomethanes during Seawater Chlorination
Published 2010“…Results of kinetic experiments have shown that concentrations of THMs increased rapidly with time during the first half hour. Chlorination of seawater has shown significant increase in total THMs (TTHMs) and in bromoform concentrations. …”
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A Comprehensive Analysis of Healthcare Big Data Management, Analytics and Scientific Programming
Published 2020“…Early decision making based healthcare system has massive potential for dropping the cost of care, refining quality of care, and reducing waste and error. Scientific programming play a significant role to overcome the existing issues and future problems involved in the management of large scale data in healthcare, such as by assisting in the processing of huge data volumes, complex system modelling, and sourcing derivations from healthcare data and simulations. …”
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The impact of an educational program on emergency nurses’ preparedness to care for domestic violence women victims
Published 2025“…All the invited nurses attended the educational program. Therefore, the response rate was 100%, and there were no attrition or withdrawal cases during the study. …”
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An arabic picture vocabulary program to develop oral language, visual imagery, and memory skills. (c2012)
Published 2016“…The student had received intensive intervention sessions for two months using an adapted version of the Visualizing and Verbalizing Program® by Lindamood-Bell. Pre-test, during-the-intervention-test, and post-test assessment used various formal and informal instruments to accurately measure the student’s progress. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Sleeping habits during COVID-19 induced confinement: A study from Jordan
Published 2021“…Intervention programs and strategies are warranted to further improve sleep during the current and future disease-induced confinement.…”
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Jordanian nurses’ attitudes toward using electronic health records during COVID-19 pandemic
Published 2022“…<p dir="ltr">Electronic health records (EHRs) have proven their effectiveness during the coronavirus disease (COVID-19) pandemic. …”
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The effects of the first wave of COVID-19 restrictions on physical activity: a longitudinal study from “step into health” program in Qatar
Published 2024“…Participants with higher physical activity levels pre-covid experienced significant decline in step count during and even after restrictions were uplifted.…”
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One year of alcohol-related road traffic Injuries in Qatar: Results from the Hamad Trauma Center Alcohol Screening Program
Published 2015“…This study will report the results of the Alcohol Screening Brief Intervention and Referral for Treatment [ASBIRT] Program of the Hamad Trauma Center [HTC]. This ASBIRT is a program of the HTC, the only Level I Trauma Center in Qatar. …”