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Association between Healthy Lifestyle Index and Cognitive decline In Community- Dwelling Lebanese Older Adults
Published 2021“…Objective: Normal aging is often associated with cognitive deterioration in older adults, but the prevalence of cognitive decline like cognitive impairment, Alzheimer’s disease and dementia has been increasing lately. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Lower limb EMG activation during reduced gravity running on an incline. Speed matters more than hills irrespective of indicated bodyweight
Published 2021“…Increasing running speed was associated with the largest change in activity, with smaller effects for increasing bodyweight and inclination. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Prevalence and risk of cognitive impairment among patients with asthma: A systematic review and meta‐analysis
Published 2025“…The results underscored the substantial correlation between asthma and heightened risks of cognitive decline, dementia, and Alzheimer's disease.</p><h3>Conclusion</h3><p dir="ltr">This review found a notable association between asthma and an increased risk of cognitive decline, including dementia and Alzheimer's disease. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Board changes and CEO turnover
Published 2014“…For firms that decrease independence, the CEO turnover performance sensitivity significantly decreases following SOX. …”
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Examining time-to-transport decisions in Emergency Medical Services
Published 2024“…The Schoenfeld plot (Figure 2) demonstrates that multiple variables have a significant impact on increasing the time-to-handover.…”
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CFD Study of Particle Concentration and Stokes Number Effect on Erosion Profile.
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Screen Time Soars and Vision Suffers: How School Closures During the Pandemic Affected Children and Adolescents’ Eyesight
Published 2024“…Furthermore, logistic regression analysis showed that local students and those with a history of visual disturbances were 1.7 times (AOR: 1.73, 95%CI 1.18–2.54, <i>p</i> = 0.005) and 2.5 times (AOR: 2.52, 95%CI 1.69–3.76, <i>p</i> < 0.001) more likely to experience decline of visual acuity respectively. School closures in Qatar were associated with a significant increase in screen time among students and a notable decline in their visual acuity. …”
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Characteristics of aerosols and planetary boundary layer dynamics during biomass burning season
Published 2025“…The results illustrate the key contributors to this haze event and showed the there is significant increases in aerosol components such as sulfate, black carbon, organic carbon, dust and aerosol optical depth (AOD). …”
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Symptoms of depression and anxiety in anorexia nervosa
Published 2014“…We speculate that enhanced TRP availability during re-feeding, as a result of the increase in the TRP/LNAA ratio, could restore serotonin neurotransmission and lead to a decrease in depressive symptoms. …”
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Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC
Published 2025“…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …”