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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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An integrative comparative study between ultrasound-guided regional anesthesia versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: A...
Published 2022“…</p><h3>Results</h3><p dir="ltr">A Meta-analysis of the seven studies showed that ultrasound-guided femoral nerve block was more effective than parenteral opioids in relieving pain. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Machine Learning Approach for Effective Ranking of Researcher Assessment Parameters
Published 2023“…<p dir="ltr">The measurement and assessment of academic performance is now a fact of scientific life. This assessment guides the scientific community in making significant judgments such as selecting appropriate candidates for various positions, nominating individuals for scientific awards, and awarding scholarships or grants. …”
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Solving the Narrow Corridor Problem in Potential Field-Guided Autonomous Robots
Published 2005“…This paper tackles the issue of converting the guidance signal from the gradient of a potential field into a control signal that can both guide an autonomous robot and effectively manage its dynamics. …”
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Effective use of Science Inquiry-based Teaching on Student Achievement and Engagement
Published 2019“…This paper investigates the impact the science-inquiry teaching approach and evaluates its effectiveness on the students‘ achievement and engagement level over four months and a half. …”
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Effects of Different Processing Methods on the Antibiotic Enrofloxacin Residues Occurrence in Middle Eastern Dairy Products
Published 2020“…Pressing Baladi to produce Akkawi did not have any significant effect on ENF concentration, while boiling Akkawi to produce Halloum decreased it significantly. …”
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An Energy-Water-Food Nexus-based Decision-making Framework to Guide National Priorities in Qatar
Published 2021“…Results of this study offer a generic roadmap that can be followed by countries to set national priorities based on evidence-informed performance assessments reflecting resources ‘conditions optimal and cost-effective decisions that meet the need of the targeted population.…”
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