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New susceptibility loci associated with type 2 diabetes. (c2011)
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants
Published 2006“…The magnitude of drug interactions between azole antifungals and immunosuppressants is drug and patient specific and depends on the potency of the azole inhibitor involved, the resulting plasma concentrations of each drug, the drug formulation, and interpatient variability. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Substrate Dependent Analysis of Printed Sensors for Detection of Volatile Organic Compounds
Published 2019“…<p>This paper investigates all-printed gas sensors developed on different unconventional substrates and their effect of the detection of various volatile organic compounds (VOCs). …”
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The effects of Social Determinants of Health on Type 2 Diabetes Outcomes (A1C)
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Damage assessment and recovery from malicious transactions using data dependency for defensive information warfare
Published 2007“…Since even segmenting the log into clusters may not solve the problem, as clusters/segments may grow to be humongous in size, this is in case of high data/transaction dependency, we suggest a method for segmenting the log into clusters and its sub-clusters; i.e, segmenting the cluster; based on exact data dependency [12], into sub-clusters; based on two different criteria: number of data items or space occupied. …”
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The pro-apoptotic effect of kefir in malignant T-lymphocytes involves a p53 dependent pathway
Published 2013“…Methods: CEM cells (HTLV-1 negative) and HUT-201 cells (HTLV-1 positive) leukemic cells were incubated with different concentrations of a cell free fraction of kefir. …”
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Sex differences in shoulder performance fatiguability are affected by arm position, dominance and muscle group
Published 2022“…There was a significant difference between the ER and IR muscles, with significantly higher values observed for the IR in C.Perf (mean difference = 331.74 J) by 30.0% and in BR (mean difference = 13.31 J) by 26.64%. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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