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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…This is specifically relevant in designing assays that require bioluminescence for extended periods, such as in the case of biosensors designed for monitoring slow enzymatic or <u>cellular signaling</u> reactions, without necessitating multiple rounds of luciferase substrate addition or any specialized reagents that result in increased assay costs. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Application and comparison of dynamic routing models for unsteady flow in simple and compound channels
Published 1992“…The first, which viewed the composite flow field as a single hydraulic unit without storage, produced significant differences between simulated and observed stage and discharge hydrographs. …”
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Application of bipolar membrane (BPM)-based technology to green energy and environmental sustainability
Published 2025“…A key contribution of this study is the detailed analysis of bipolar membrane <u>electrodialysis</u> (BMED), an innovative process that produces acids and bases from salt solutions without chemical additives, offering enhanced energy efficiency and reduced environmental impact. …”
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Rapid mercury removal using living indigenous microalgal communities for water treatment applications
Published 2025“…Kinetic studies showed superior correlation with the pseudo-second-order model (R<sup>2</sup> > 0.996), with rate constants decreasing systematically from 767.5 to 216.0 g/mg·min as concentration increased, suggesting secondary chemical interactions may also contribute to the overall mechanism. …”
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Influence of silica calcination temperature on the performance of supported catalyst SiO2–nBuSnCl3/MAO/(nBuCp)2ZrCl2 polymerizing ethylene without separately feeding the MAO cocata...
Published 2020“…Abstract The effects of support calcination temperature, an important catalyst synthesis parameter, on the overall performance of the supported catalyst [silica ES70–nBuSnCl3/MAO/(nBuCp)2ZrCl2], polymerizing ethylene without separately feeding the MAO cocatalyst, were studied. …”
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Response of cauliflower (<i>Brassica oleracea</i> L.) to nitric oxide application under cadmium stress
Published 2022“…The concentration of malondialdehyde (MDA) and Cd accumulation (roots and shoots) increased significantly (P < 0.05) under the increasing levels of Cd in all genotypes of B. oleracea while antioxidant (enzymatic or non-enzymatic) capacity and nutritional status of the plants was decreased with varying levels of Cd in the sand. …”
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The Application of International Humanitarian Law Principles to Autonomous Weapon Systems in Armed Conflicts: Current and Future Prospects
Published 2023“…These systems, which are capable of performing tasks without human intervention, have the potential to revolutionize the way wars are fought and make significant impact on international security. …”
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Voltage Lift Switched Inductor Double Leg Converter With Extended Duty Ratio for DC Microgrid Application
Published 2021“…This novel converter has the feature of attaining a very high voltage without using any complex circuitry such as transformer, multiple voltage lift circuits, cascaded or parallel structure, etc. …”
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