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Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping
Published 2024“…We identify 184 protein-altering variants in 137 genes that are significantly associated with their corresponding variant peptides, confirming target specificity of co-associated affinity binders, identifying putatively causal cis-encoded proteins and providing experimental evidence for their presence in blood, including proteins that may be inaccessible to affinity-based proteomics.…”
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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn...
Published 2020“…Individuals with serum 25(OH)D ≥75 nmol/L had significantly lower waist circumference (<i>p</i> < 0.0001), C-reactive protein (<i>p</i> = 0.003), glycated hemoglobin (<i>p</i> < 0.0002), fasting triglycerides (<i>p</i> < 0.0001), total homocysteine (p < 0.0001), and insulin resistance (<i>p</i> = 0.0001) and had significantly higher HDL-cholesterol (<i>p</i> < 0.0001) and maximal oxygen uptake (marker for CRF) (<i>p</i>< 0.0009) compared to those with 25(OH)D <30 nmol/L. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM
Published 2020“…Interestingly, interrogation of the expression levels of hsa-miR-205 and hsa-miR-214 in the METABRIC breast cancer dataset revealed significantly poor overall survival in patients with downregulated expression of miR-205 [HR = 0.75 (0.61–0.91)], p = 0.003 and hsa-miR-214 [HR = 0.74 (0.59–0.93) p = 0.008]. …”
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Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
Published 2025“…However, in the past two decades Gulf mangroves have been facing significant threats, including extensive coastal development, shoreline modification by establishing marinas and ports, and climate change-associated impacts such as sea-level rise and altered precipitation patterns, which pose significant risks to this fragile ecosystem. …”
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Bacteriuria in pregnancy varies with the ambiance: a retrospective observational study at a tertiary hospital in Doha, Qatar
Published 2023“…<h3>Objectives</h3> <p>To explore the influence of ambient temperature and humidity on significant bacteriuria (SB) and urinary bacterial isolates in pregnant women.…”
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Beyond radicalization: the 3N model and its application to criminal attitudes in high-risk contexts
Published 2025“…Study 2 further tested a field intervention using positive role models to mitigate the search for meaning and criminal attitudes.</p><h3 dir="ltr">Results</h3><p dir="ltr">Findings from Studies 1A and 1B indicate a significant indirect effect of the search for meaning on criminal attitudes, mediated through deviant associations. …”
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Artisanal fishing of spiny lobsters with gillnets — A significant anthropic impact on tropical reef ecosystem
Published 2015“…The analysis of target species using nocturnal visual census demonstrated a significantly higher number of P. echinatus at the site where gillnet use was virtually absent within three sampled habitats, fringe, cave and soft bottom. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Sleep and Sleep Disorder Knowledge Among Physicians Working in Qatar’s Primary Health Care Corporation: A Cross-Sectional Study<p></p>
Published 2026“…<p dir="ltr">Sleep is a fundamental biological process essential for physical, cognitive, and mental health, yet sleep disorders remain underrecognized in primary care. …”
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Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation
Published 2024“…Functional assays revealed that miR-222-5p overexpression led to a significant increased expression of key pro-inflammatory cytokines, including IL-8 and TNF-α, while knockdown of these miRNAs resulted in their decreased expression. …”
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Sugar-Sweetened Beverages Contribute Significantly to College Students’ Daily Caloric Intake in Jordan: Soft Drinks Are Not the Major Contributor
Published 2019“…<div><p>Sugar sweetened beverages (SSBs) are caloric-dense and associated with poor diet quality which may result in weight gain and obesity. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank
Published 2025“…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R2 = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …”
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Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank
Published 2024“…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R<sup>2</sup> = 0.065, ΔF(7, 1724) = 3.34, p= 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …”