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Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
Published 2018“…Here, we perform differential epithelium-stroma proteomic network analyses to characterize signaling pathways associated with TRIM28 within the tumor microenvironment.…”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Beyond radicalization: the 3N model and its application to criminal attitudes in high-risk contexts
Published 2025“…</p><h3 dir="ltr">Results</h3><p dir="ltr">Findings from Studies 1A and 1B indicate a significant indirect effect of the search for meaning on criminal attitudes, mediated through deviant associations. …”
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Artisanal fishing of spiny lobsters with gillnets — A significant anthropic impact on tropical reef ecosystem
Published 2015“…The analysis of target species using nocturnal visual census demonstrated a significantly higher number of P. echinatus at the site where gillnet use was virtually absent within three sampled habitats, fringe, cave and soft bottom. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Association of neighborhood deprivation and hypertension: a systematic review and meta-analysis
Published 2024“…</p><h3>Conclusion</h3><p dir="ltr">Our analysis confirms a significant association between neighborhood deprivation and hypertension, underscoring the importance of socioeconomic factors in public health. …”
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Genetic polymorphisms associated with obesity in the Arab world: a systematic review
Published 2021“…A total of 76 variants located within or near 49 genes were reported to be significantly associated with obesity. …”
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Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India
Published 2023“…</p><h3>Results</h3><p dir="ltr">Our findings revealed significant associations of TERT rs10069690 and POT1 rs10228682 with NSCLC risk (adjusted p-values = 0.019 and 0.002, respectively), while TERF2 rs251796 and rs2975843 showed no significant associations. …”
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Epidemiology, clinical characteristics, and associated cost of acute poisoning: a retrospective study
Published 2024“…The mean length of hospital stay was found to be 1.84 ± 0.81 days, and most patients (76.6%) were discharged within the first 8 h. A statistically significant difference was found between age groups and type of toxin (χ<sup>2</sup> = 23.3, p < 0.001), cause and route of exposure (χ<sup>2</sup> = 42.2, <i>p</i> < 0.001), and length of hospital stay (χ<sup>2</sup> = 113.16, <i>p</i> < 0.001). …”
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Evaluating the role of environmental concern, risk perception and stakeholder salience in driving sustainable water consumption within sustainability project initiatives in the UAE...
Published 2017“…The results indicate that individual determinants were significantly associated with sustainable water consumption strategies and practices. …”
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Application of Data Mining to Predict and Diagnose Diabetic Retinopathy
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