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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Ensemble deep learning for brain tumor detection
Published 2022“…We experiment on an MRI brain image dataset. First, the data is preprocessed efficiently, and then, the Convolutional Neural Network (CNN) is applied to extract the significant features from images. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Deep learning for brain electron microscopy segmentation: Advances, challenges, and future directions in connectomics and ultrastructure analysis
Published 2025“…The meta-analysis demonstrates that foundation models outperform traditional CNNs by 13%–35% across key metrics, with the 3D Transformer + U-Net achieving the highest composite score (0.954) across five datasets. Meta-analysis confirms significant advantages for foundation models in instance-based metrics (Cohen’s d =− 6 . 44 ), while only 26% of experiments validate across multiple datasets. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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An Efficient Brain Tumor Segmentation Method Based on Adaptive Moving Self-Organizing Map and Fuzzy K-Mean Clustering
Published 2023“…This research utilized the online Kaggle Brats-18 brain tumor dataset. This dataset consisted of 1691 images. …”
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Differentially expressed miRNA profiles of serum derived extracellular vesicles from patients with acute ischemic stroke
Published 2024“…These pathways are crucial for cellular function and stress response, and their dysregulation can have significant implications for the disease processes. …”
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A novel method for the detection and classification of multiple diseases using transfer learning-based deep learning techniques with improved performance
Published 2024“…<p dir="ltr">A disease is a distinct abnormal state that significantly affects the functioning of all or part of an individual and is not caused by external harm. …”
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Exploring Effects of Mental Stress with Data Augmentation and Classification Using fNIRS
Published 2025“…These findings illustrate the ability to detect changes in brain states with high accuracy using fNIRS, underline the need for larger datasets, and demonstrate that data augmentation can significantly help when data are scarce in the case of brain signals.…”
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