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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Construction Disputes in the UAE: Causes and Resolution Methods
Published 2020“…The sources of disputes, and their avoidance/resolution methods, were identified through a comprehensive literature review. …”
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Business Streamlining: Towards Sustained Business Process Improvement with implementation of Total Quality Management Tools
Published 2023“…These factors were then prioritized using a Pareto chart, targeting the most significant issues that account for 80% of the process inefficiencies. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Identifying the Inherent Factors Causing Delays in the UAE Construction Industry
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Causes of Delay in Construction Projects in Oil and Gas Construction Industry
Published 2017“…Issues related to client performance included bureaucracy and late honouring of certificates. Secondary causes such as rework, the rate of productivity, dispute management and delay analysis were also found to have great significance. …”
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Genome-Based Characterization of Bacterial Pathogens Causing Bloodstream Infection
Published 2024“…Whole-genome sequencing, Replicon Typing, and the Kirby-Bauer disk diffusion test were used for in-depth resistance and virulence characterization. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd...
Published 2021“…Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. …”
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Prevalence and clinical significance of antiphospholipid antibodies in patients with coronavirus disease 2019 admitted to intensive care units: a prospective observational study
Published 2022“…A total of 60 critically ill patients were enrolled. Among them, 57 (95%) were men, with a mean age of 52.8 ± 12.2 years, and the majority were from Asia (68%). …”