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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
Published 2025“…<p>Accurate control of wave energy devices relies heavily on precise forecasts of wave heights, yet the dynamic and fluctuating nature of historical wave data presents significant challenges to achieving this precision. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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An Efficient Test Vector Compression Technique Based on Geometric Shapes
Published 2001“…One of the prime challenges of testing a system-on-a-chip (SOC) is to reduce the required test data size. …”
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Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
Published 2016“…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Design and Testing of LCC-Compensated Dynamic Wireless Electric Vehicle Charging System
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Willingness to participate in genome testing: a survey of public attitudes from Qatar
Published 2020“…Willingness to participate was significantly associated with basic literacy in genetics, a family history of genetic diseases, and previous experience with genetic testing through premarital screening. …”
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Arabic Dialect Speech-Text Recognition Using Deep Learning
Published 2024“…The Hybrid TestRCNN-CNN Model outperforms the TestRCNN, achieving an accuracy of 94% and significantly reducing the (WER) to 0.0460. …”
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Packed‐Bed Microreactor Under Taylor Flow for MOFs Catalyst Testing Demonstrated on Phenylacetylene Hydrogenation
Published 2024“…This study addresses the challenge of testing limited amounts of MOF catalysts for demanding applications, such as multiphase gas‐liquid‐solid reactions in flow, utilizing a packed‐bed microreactor. …”