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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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A Multidecadal Assessment of Drought Intensification in the Middle East and North Africa: The Role of Global Warming and Rainfall Deficit
Published 2025“…We employed the CRU TS v. 4.07 datasets to assess changes in drought characteristics (e.g., frequency, intensity, duration, and severity) at the 12-months timescale for the main Koppen-Geiger climate zones in the region. …”
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A novel sentiment analysis framework for monitoring the evolving public opinion in real-time: Case study on climate change
Published 2021“…The developed solution encompasses a sophisticated Bi-directional LSTM classifier that was implemented and tested using a dataset consisting of 278,000 tweets related to the topic of climate change. …”
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Beyond economic growth goals: can foreign aid mitigate carbon dioxide emissions in developing countries?
Published 2024“…<p>We provide novel and compelling evidence that foreign aid has significant mitigating impacts on carbon dioxide emissions in a comprehensive panel dataset of 127 developing countries from 1995 to 2019. …”
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Short-term behavioural responses to thermal stress by hawksbill turtles in the Arabian region
Published 2014“…We used 66 of these datasets, where turtles clearly departed and returned to foraging grounds, for these analyses. …”
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Investigation of Groundwater Depletion in the State of Qatar and Its Implication to Energy Water and Food Nexus
Published 2021“…Long-term temperature data indicates that the annual mean temperature increased significantly by 1.02 °C between 1987 and 2016, while total rainfall exhibited a slight decreasing trend. …”
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Does trade openness mitigate environmental degradation in Organisation for Economic Co‐operation and Development (OECD) countries? Implications for achieving sustainable developmen...
Published 2024“…<p dir="ltr">The link between trade openness and CO<sub>2</sub> emissions is a key research focus in times of pressing global sustainability needs and ongoing climate change discussions. In this study, we address the critical issue of the impact of trade openness on CO<sub>2</sub> emissions in 20 OECD countries over a 150‐year period using historical datasets. …”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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