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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Board changes and CEO turnover
Published 2014“…We consider actual board changes made by compliant firms and how such changes affect the monitoring efficiency of the boards. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Effect of Climate Change on the Energy Performance and Thermal Conditions of a Single-family Detached House in Canada
Published 2019“…In conclusion, buildings designed based on historical weather data would perform differently under the changing future climates, thus the efforts should be made to design buildings that would be adaptable to climate change.…”
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21st Century Warfare: How Information Technology Has Fundamentally Changed Global Warfare - An Analysis of Insurgencies’ Use of IT
Published 2018“…The 21st century has seen a change in the type of warfare waged globally. Whereas the 20th century was characterized by decolonization and states warring against one another, the 21st century has witnessed a shift in global warfare where non-state actors such as radical groups are gaining momentum and causing significant mayhem. …”
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A critical review of phase change material composite performance through Figure-of-Merit analysis: Graphene vs Boron Nitride
Published 2021“…A considerable research effort is being made to address the low thermal conductivity of PCMs using thermally conductive nanofillers. …”
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Oral contraceptive pills and possible adverse effects
Published 2014“…Since their introduction to the market, there have been significant changes in the drug content and formulations of these products, in part to decrease the risk of adverse effects. …”
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Effect of COVID-19 on the Generation of Waste in Marrakech, Morocco
Published 2021“…In addition, changes in living conditions can induce significant variation in the quantitative and qualitative characteristics of waste.…”
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Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries
Published 2023“…The results indicate that non-oil real GDP exhibits an adverse and magnified response to an increase in remittance outflows, relative to a decrease. …”
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