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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients
Published 2022“…No other associations of the measured parameters were seen for any of the other CRIS subtypes. …”
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Machine Learning Based Photovoltaics (PV) Power Prediction Using Different Environmental Parameters of Qatar
Published 2019“…<div><p>Photovoltaics (PV) output power is highly sensitive to many environmental parameters and the power produced by the PV systems is significantly affected by the harsh environments. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Relational pre‑impact assessment of conventional housing features and carbon footprint for achieving sustainable built environment
Published 2022“…The results of this study show a positive and statisti cally significant linear relation of carbon footprint with the area, volume, and power rating parameters. …”
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Label dependency modeling in Multi-Label Naïve Bayes through input space expansion
Published 2024“…Multi-label techniques often employ a similar feature space to build classification models for every label. …”
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MACGAN: An All-in-One Image Restoration Under Adverse Conditions Using Multidomain Attention-Based Conditional GAN
Published 2023“…The results confirm that both components play significant roles in the effectiveness of MACGAN, with the discriminator ensuring adversarial training and the attention blocks effectively capturing and enhancing important image features.…”
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Optimizing Document Classification: Unleashing the Power of Genetic Algorithms
Published 2023“…BERT generates a 768-dimensional vector for each record, which introduces significant time complexity during computation. Additionally, our proposed model optimizes the features using a genetic algorithm. …”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…Only Cisplatin treatment caused a significant decrease in body weight and increase in serum ALT. …”
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