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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Whole-genome Sequences of Multidrug-Resistant Escherichia coli
Published 2023“…Our study revealed the diversity within E. coli clinical isolates and the role of mobile elements in disseminating resistance determinants. Whole-genome sequencing significantly enhanced infectious disease surveillance, our understanding of transmission dynamics, and the detection of antimicrobial resistance determinants.…”
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Distinct genomic features across cytolytic subgroups in skin melanoma
Published 2022“…We questioned whether CYT associates with different genomic profiles and thus, patient outcome, in skin melanoma.…”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Whole-Genome Molecular Characterization and Typing of Staphylococcus aureus Isolated from Lebanon
Published 2020“…The rising prevalence of multidrug resistant (MDR) S. aureus in both community and hospital settings is a significant public health concern. In this study, whole-genome sequencing was used for the molecular characterization of 31 S. aureus clinical isolates. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Comparative Metagenomics of Cedar Forest Soils in Lebanon: Uncovering Microbial Diversity and Ecological Patterns
Published 2025“…Understanding these microbial patterns is critical for developing informed conservation strategies and guiding ecosystem management practices in biodiversity-rich forest habitats.…”
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Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits
Published 2021“…We identify 281 distinct variant-trait-associations at genome wide significance that replicate known associations. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci
Published 2012“…LINE-1 repeats account for ∼17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted. …”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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masterThesis