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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The Role of Project Management Soft Skills in Increasing Project Success
Published 2017“…As the world economy shifts towards an increasingly globalised market, the degree of competition becomes a more significant challenge which organisations face. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …”
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Prevalence and clinical significance of antiphospholipid antibodies in patients with coronavirus disease 2019 admitted to intensive care units: a prospective observational study
Published 2022“…<p>Coronavirus disease 2019 (COVID-19) increases the risk of coagulopathy. Although the presence of antiphospholipid antibodies (aPLs) has been proposed as a possible mechanism of COVID-19-induced coagulopathy, its clinical significance remains uncertain. …”
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Influence of Cognitive Bias on Decision Making in Mega Projects
Published 2020“…On the other hand, availability, anchoring, dread, and familiarity were found to significantly influence cost decision making, the other biases had no significant influence on cost decision making implying these biases have an influence on cost overrun through decision making. …”
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Habitat Complexity Influences the Microhabitat Choices of Desert Beetles
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Factors Influencing the Adoption and Implementation of Predictive Maintenance Technologies in Organizations
Published 2023“…Significant research has explored the numerous advantages of predictive maintenance technologies. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Influence of thermo-mechanical properties of coatings on friction in elastohydrodynamic lubricated contacts
Published 2015“…In a previous work by the author, it was shown that thermal properties of coatings had a significant influence on friction. In fact, under high sliding speeds, friction was found to increase with the thermal inertia of coatings. …”
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Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes
Published 2015“…Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia. …”
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Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC
Published 2025“…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …”
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Project manager perceptions factors influencing the delivery of successful innovation in construction projects
Published 2018“…The main findings show that there is an influence of project manager perceptions factors on delivering successful innovation at a construction project level with evidence that his leadership, capabilities/competences, personality traits, and skills (non-engineering skills) are relatively important for the significance influence. …”
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Investigating the Influence of the Individual Empowerment and Cultural Intelligence on the Emergence of Innovation in the Public Sector.
Published 2019“…Hence, this research confirms that employee empowerment influenced by cultural intelligence would increase the emergence of innovation in the public sector higher education service providers within the defined InE.…”
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