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interactions sup » interactions _ (Expand Search), interactions a (Expand Search)
increased » increase (Expand Search)
decrease » increase (Expand Search)
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Chronic reduction of store operated Ca<sup>2+</sup> entry is viable therapeutically but is associated with cardiovascular complications
Published 2022“…</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca<sup>2+</sup> influx through store-operated Ca<sup>2+</sup> entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Rapid mercury removal using living indigenous microalgal communities for water treatment applications
Published 2025“…Kinetic studies showed superior correlation with the pseudo-second-order model (R<sup>2</sup> > 0.996), with rate constants decreasing systematically from 767.5 to 216.0 g/mg·min as concentration increased, suggesting secondary chemical interactions may also contribute to the overall mechanism. …”
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Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket
Published 2023“…Our data reveal that the E105A mutation has a significant negative effect on the interaction of CaM with both RyR2 regions in the presence and absence of Ca<sup>2+</sup>, highlighting the potential contribution of these two human RyR2 regions to an RyR2 CaM-binding pocket, which may be essential for physiological CaM/RyR2 association and thus channel regulation.…”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket
Published 2023“…Moreover, our isothermal titration calorimetry ITC data suggest that RyR2 3584-3602aa and 4255-4271aa regions interact with significant affinity with wild-type CaM, in the presence and absence of Ca<sup>2+</sup>, two regions that might contribute to a putative intra-subunit CaM-binding pocket. …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…Only Cisplatin treatment caused a significant decrease in body weight and increase in serum ALT. …”
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Effect of Crude Oil Products on the Geotechnical Properties of Sandy Soil
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Hyperspectral-physiological based predictive model for transpiration in greenhouses under CO<sub>2</sub> enrichment
Published 2023“…The XGBoost model outperformed the DNN and SVR models with higher R<sup>2</sup> of 0.62 – 7.53%, lower RMSE and MAE values of 9.74 – 46.19 mmol/m<sup>2</sup>.s and 13.74 – 39.08 mmol/m<sup>2</sup>.s respectively with microclimate, physiological and hyperspectral based vegetation index inputs. …”
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Occupational Violence at Lebanese Emergency Departments
Published 2011“…Exposure to verbal abuse was associated with serious outcomes including significantly higher levels of occupational burnout and an increased likelihood to quit current job. …”
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