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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Temporal self-attention for risk prediction from electronic health records using non-stationary kernel approximation
Published 2024“…The experimental results demonstrate that non-stationary kernels significantly outperformed baseline methods for NDCG@10 and Hit@10 metrics in both datasets. …”
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Predictive modelling in times of public health emergencies: patients’ non-transport decisions during the COVID-19 pandemic
Published 2025“…However, some patients declined transportation to hospital due to their fear of accessing healthcare facilities. This posed a significant risk to their health outcomes. This study aimed to utilise an extensive dataset, which included the period of the COVID-19 pandemic, in a modern Middle Eastern Emergency Medical Service to comprehend and predict the behaviour of non-transport decisions, a major multi-variable factor in pre-hospital emergency medicine. …”
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Adaptive Federated Learning Architecture To Mitigate Non-IID Through Multi-Objective GA-Based Efficient Client Selection
Published 2024“…However, FL encounters significant challenges when dealing with non-independent and non-identically distributed (Non-IID) data across participating clients, such as skewed label distributions and varying data quantities. …”
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Communication-efficient hierarchical federated learning for IoT heterogeneous systems with imbalanced data
Published 2022“…We evaluate the proposed system using two real-world datasets, and we show that it outperforms state-of-the-art FL solutions. …”
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How effective are synthetic attack models to detect real-world energy theft?
Published 2025“…Data-driven approaches to electricity fraud detection have gained popularity due to smart grids’ big data. However, available datasets lack annotated real anomalies, which poses significant challenges in developing effective detection systems. …”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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