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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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A Review of Commonly Prescribed Antiviral and Antiretroviral Agents
Published 2011“…Having a strong knowledge of commonly prescribed antiviral drugs allows these frontline professionals to make a significant impact on the quality of care that they provide to their patients and community.…”
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A complete model of wet cooling towers with fouling in fills
Published 2020“…In cooling towers, a significant portion of the total heat rejected may occur in the spray and rain zones. …”
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Apportioning subcontractors’ liability for project delays; a consensus approach
Published 2020“…Main contractors sometimes run a significant risk of losing out on a major portion of their contract price to LDs for delays by subcontractors, due to the problem of not being able to recover entire LDs from their subcontractors. …”
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A practical routing model for optimized pavement data collection
Published 2017“…The routing of these vehicles, however, is often managed in an ad hoc manner with significant expense. This paper introduces a practical optimization method for designing the routes of pavement data collection equipment. …”
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Development of a Smart System for Leak Detection in Water Distribution Networks
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A Study and Assessment of the Status of Energy Efficiency and Conservation at School Buildings
Published 2022“…The building sector consumes a significant portion of global energy use. In this regard, this work was undertaken to study the status of energy efficiency and conservation at a large school building in the northern part of United Arab Emirates (UAE). …”
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Prevalence and treatment of mental disorders in Lebanon: a national epidemiological survey
Published 2006“…Background Mental disorders are believed to account for a large portion of disease burden worldwide. However, no national studies have been undertaken to assess this assumption in the Arab world. …”
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The Role of Nanofluids and Renewable Energy in the Development of Sustainable Desalination Systems: A Review
Published 2020“…<p dir="ltr">Desalination accounts for 1% of the total global water consumption and is an energy-intensive process, with the majority of operational expenses attributed to energy consumption. Moreover, at present, a significant portion of the power comes from traditional fossil-fuel-fired power plants and the greenhouse gas emissions associated with power production along with concentrated brine discharge from the process, pose a severe threat to the environment. …”
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A Comprehensive Analysis of Healthcare Big Data Management, Analytics and Scientific Programming
Published 2020“…The peer reviewed reputed journals are selected for the accumulated of published research work during the period ranges from 2015 - 2019 (a portion of 2020 is also included). A total of 127 relevant articles (conference papers, journal papers, book section, and survey papers) are selected for the assessment and analysis purposes. …”
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A novel integrated wastewater recovery, clean water production and air-conditioning system
Published 2021“…Similarly, fulfilling the water needs in water-scarce regions also consumes a large amount of energy. The consequence of this high energy and water demand are significant greenhouse gas emissions and other pollutants. …”
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Perception and Knowledge of Hospital Workers Toward Using Artificial Intelligence: A Descriptive Study
Published 2025“…Most participants were nurses (54.9%), followed by allied health professionals (20.7%), pharmacists (12.2%), and physicians (11.0%). A significant portion of participants (59.8%) reported no prior experience with AI. …”
