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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Memory synthesis for FPGA-Based reconfigurable computers
Published 2017“…An intelligent usage of these memories can lead to a significant improvement in the latency of the overall design. …”
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Energy Conservation-based Thresholding for Effective Wavelet Denoising of Partial Discharge Signals
Published 2016“…In this study, a novel wavelet threshold estimation method, named energy conservation-based thresholding (ECBT), is introduced. The proposed thresholding function is capable of conserving a significant portion of the original signal energy, while the threshold value is determined based on the relative difference between the original and noisy signal energies. …”
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Single-cell protein production from purple non-sulphur bacteria-based wastewater treatment
Published 2022“…<p>Large-scale production of single-cell protein (SCP) has the potential not only to solve some of the food insecurity and water scarcity crises that plague a significant portion of our world today but also holds the promise to reduce the cost associated with the treatment of industrial and agricultural wastewater. …”
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DiaNet v2 deep learning based method for diabetes diagnosis using retinal images
Published 2024“…<p dir="ltr">Diabetes mellitus (DM) is a prevalent chronic metabolic disorder linked to increased morbidity and mortality. With a significant portion of cases remaining undiagnosed, particularly in the Middle East North Africa (MENA) region, more accurate and accessible diagnostic methods are essential. …”
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An Investigation of the Development and Implementation of Teacher's Licensing in Saudi Arabia Based on Local Stakeholders' Perceptions, Compared to International and Regional Pract...
Published 2023“…However, promoting teacher quality concerns leaders in the education sector, and significant efforts to raise teacher quality are paramount to government leaders. …”
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The Role of Nanofluids and Renewable Energy in the Development of Sustainable Desalination Systems: A Review
Published 2020“…Moreover, at present, a significant portion of the power comes from traditional fossil-fuel-fired power plants and the greenhouse gas emissions associated with power production along with concentrated brine discharge from the process, pose a severe threat to the environment. …”
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Energy-Efficient Cell Association and Load Balancing for Low Battery Users in Heterogeneous Cellular Networks
Published 2025“…Results on cell association, load balancing, and EE of LBUs have been compared with conventional association schemes. The proposed battery based cell association models perform well in favor of LBUs and clearly show the significance of the proposed approach.…”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…Only Cisplatin treatment caused a significant decrease in body weight and increase in serum ALT. …”
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