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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents
Published 2020“…The current study evaluates light-activated ruthenium prodrugs and their photoproducts as potential anti-cancer agents. The complexes being investigated are: [Ru(bpy)2phen]Cl2 (unstrained), [Ru(bpy)2BC]Cl2, [Ru(bpy)2dpphen]Cl2. …”
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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants
Published 2006“…Many factors contribute to variability in the magnitude and clinical significance of drug interactions between an immunosuppressant such as cyclosporine, tacrolimus, or sirolimus and an antifungal agent such as ketoconazole, fluconazole, itraconazole, voriconazole, or posaconazole. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
Published 2021“…Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer photothermal therapy. To be most effective, photothermal agents need to be internalized by the cancer cells. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Competition vs cooperation: An agent based model for sustainable tomatoes’ import system
Published 2024“…Based on the research findings, a competitive global market can bring economic benefits to Qatar as an importing nation, but this approach also entails substantial <u>water consumption</u> and results in significant environmental emissions. Conversely, collaboration among exporting countries demonstrates a potential 20% reduction in water usage and a 15% decrease in environmental emissions compared to the competitive scenario, offering enhanced environmental performance albeit at<u> higher economic costs</u>. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
Published 2022“…The use of natural products as anticancer agents is an acceptable therapeutic approach due to accessibility, applicability, and reduced cytotoxicity. …”
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Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer
Published 2022“…Curcumin (CUR), extracted from Curcuma longa, has received significant attention by scientists as possible alternative to chemotherapeutic agents. …”
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Nasturtium officinalis water extract. (c2009)
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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A Principal-Agent Approach for the Effective Design of a Renewable Energy Incentive for a Heavily Subsidized Residential Sector: The Case of Qatar
Published 2023“…The study quantifies the potential impact of the policy over a period of five years and estimates that 495 GWh of electricity could be saved, resulting in a significant reduction of 203,710 Tons of CO2e emissions. …”
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Photoactivated carbon dots immobilized on cellulose for antibacterial activity and biofilm inhibition
Published 2025“…Carbon dots (CCM-PBA-NH₂) were synthesized and examined for their potential as photo-activated antimicrobial agents to address this issue. …”
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