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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…In conjunction with these data, whole-cell electrophysiological studies revealed that this concentration had maximum effect on membrane potentials, conductance and currents. Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Role of mineral-forming bacteria in mangrove rhizosphere in enhancing coastal soil stability, carbon sequestration, and heavy metals removal
Published 2025“…<u>Heavy metals</u> accumulate in fish and can potentially enter <u>human food chains</u> through consumption. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Exploring the Transformative Potential of Generative AI in Mechanical Engineering Education
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Adoption of blockchain technology in healthcare systems: benefits, potential applications, and challenges
Published 2024Get full text
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Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba
Published 2019“…Conclusions: The present study indicates that ion transporters are involved in sensory perception of A. castellanii suggesting their value as potential therapeutic targets to block cellular differentiation that presents a significant challenge in the successful prognosis of Acanthamoeba infections.…”
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Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents
Published 2020“…In conclusion, this study demonstrates that [Ru(bpy)2BC]Cl2 is a multi-mechanistic PACT drug which exhibits promising in vitro and in vivo anti-cancer potentials. It also reveals that [Ru(bpy)(dpphen)H2O]Cl2, the aquated form of [Ru(bpy)2dpphen]Cl2 photoproduct, has in vitro and in vivo anticancer activity and could be used as a chemotherapeutic agent.…”
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Income Tax-Free to Taxed: Assessing the Socioeconomic Impacts of Potential Income Tax in the UAE
Published 2025Get full text
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Investigating the Physical Properties of FeCu and its Potential use in Dye Sensitized Solar Cells
Published 2021Get full text
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Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing
Published 2023“…The results showed that the addition of Mg has a significant impact on PLA’s thermal and structural properties and has also significantly increased the degradation of PLA. …”