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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Prognostic significance of histopathological response to preoperative chemotherapy in unilateral Wilms' tumor: An analysis of 899 patients treated on the SIOP WT 2001 protocol in t...
Published 2021“…CN-WT and STN-WT96-99 groups showed significantly better EFS than RR-WT67-95 (<i>P</i> = .003 and <i>P</i> = .02, respectively), which remained significantly superior when adjusted for age, local stage and metastasis at diagnosis, in multivariate analysis, whereas OS were superimposable (97.3 ± 1.5% SE for CN-WT; 97.8 ± 1.5% SE for STN-WT96-99; 94.7 ± 1.0% SE for RR-WT67-95). …”
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Environmental and Economic Life Cycle Analysis of Primary Construction Materials Sourcing Under Geopolitical Uncertainties: A Case Study of Qatar
Published 2019“…However, the increase in distance coupled to the majority shift from land to sea-based transport resulted in an overall increase in carbon emissions and costs post-crisis. In addition, the analysis of the environmental and economic impact assessment using the average CO<sub>2</sub> equivalent (CO<sub>2</sub>-e) per kilogram and the unit price of the five primary construction materials has shown a significant, 70.68% increase in global warming potentials (GWP) after the crisis, coupled with an increase in the overall cost. …”
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Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
Published 2011“…This dissertation attempts to study the significance of staff professional development for educators and how it can affect students’ achievement. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Exploring Academic Integrity in Primary Education: Challenges, Strategies, and Impact
Published 2023“…This study explores promoting academic integrity in primary education, examining its definition, challenges, effective strategies, and implications. …”
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The retention of health human resources in primary healthcare centers in Lebanon
Published 2012“…Of particular interest is the effect of such a trend on the primary healthcare (PHC) sector; considered a cornerstone in any effective healthcare system. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Exploring of the gender variations in 4Cs skills among primary students
Published 2024“…The study used a mixed-method involving qualitative observations of facilitators feedback, quantitative paired t-test and SWOT (strengths, weaknesses, opportunities and threats) analysis to evaluate students’ 4C skills. Results of the study revealed that there were statistically significant differences between males and females. …”
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Activation of Src kinase in primary colorectal carcinoma An indicator of poor clinical prognosis
Published 2002“…Expression of u-PAR was determined by enzyme linked immunoabsorbent assay. The primary tumor-to-normal mucosa ratios of activity were compared following classification and regression tree (CART) analysis to determine the prognostic significance of elevated specific Src activity. …”
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Satisfaction of primary care physicians towards initiation of phone consultations during the COVID-19 pandemic management in Qatar: a cross-sectional study
Published 2022“…Also, only 20.3% and 3.8% of physicians were satisfied and highly satisfied with the lack of physical examination in telephone consultations, respectively. On bivariate analysis, primary care physicians’ age was significantly associated with the perceived level of impact of COVID-19 management on daily practice (<i>P</i> = 0.03). …”
