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regulates » regulate (Expand Search), regulated (Expand Search), regulators (Expand Search)
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miRNA-dependent regulation of STIM1 expression in breast cancer
Published 2019“…Here we investigate the role of the microRNA machinery in regulating STIM1 expression. We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expression in the luminal non-aggressive MCF7 breast cancer cell line. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…In such a case our method is able to identify some recently reported master regulators as well as novel important candidates.</p><h3>Conclusions</h3><p dir="ltr">We show that our network differencing procedure can effectively and efficiently detect statistical significant network re-wirings in different conditions. …”
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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Published 2019“…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases
Published 2021“…Changes in palladin expression have also been observed in invasive tumors like breast and pancreatic cancer. …”
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The combinatory effects of diet and exercise on BDNF gene expression
Published 2017“…Results showed that high protein diets induced BDNF expression and that combining this diet with voluntary exercise had an additive effect on BDNF expression. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Dysregulated FOXM1 signaling in the regulation of cancer stem cells
Published 2022“…<p>Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have been made in understanding the functional and biological plasticity of these elusive components in malignancies. …”
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Differing endometrial expression of calcium modulating transient receptor potential channels
Published 2021“…<p dir="ltr">To the editor</p><p dir="ltr">Assisted reproductive techniques (ART) have increased the live birth success rate, but there is still a significant implantation failure rate. Epithelial cell calcium homeostasis is tightly regulated by mechanisms that include activation of the TRP channel superfamily of 9 families including TRPC (Canonical) [1]. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Gene expression data analysis identifies multiple deregulated pathways in patients with asthma
Published 2018“…The data highlight the multifactorial nature of asthma, but revealed no significant overlap with the gene expression profiles from different datasets interrogated in current studies. …”
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Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression
Published 2020“…<p dir="ltr">Several phytochemicals have been identified for their role in modifying miRNA regulating tumor progression. miRNAs modulate the expression of several oncogenes and tumor suppressor genes including the genes that regulate tumor angiogenesis. …”
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Transcriptome analysis of Escherichia coli K1 after therapy with hesperidin conjugated with silver nanoparticles
Published 2021“…Significant regulation was observed for metabolic genes and several genes involved in the coordination of flagella. …”
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