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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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R<sup>2</sup>S100K: Road-Region Segmentation Dataset for Semi-supervised Autonomous Driving in the Wild
Published 2024“…To this end, we introduce Road Region Segmentation dataset (R<sup>2</sup>S100K)—a large-scale dataset and benchmark for training and evaluation of road segmentation in aforementioned challenging unstructured roadways. …”
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Image-Based Air Quality Estimation Using Convolutional Neural Network Optimized by Genetic Algorithms: A Multi-Dataset Approach
Published 2025“…Specifically, three different open-access datasets were combined into a single training dataset, capturing extensive temporal, spatial, and environmental variability. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature
Published 2019“…Increase in ACSL1 transcript abundance during sepsis was confirmed in several independent datasets. Querying the ACSL1 literature also confirmed the absence of reports associating ACSL1 with sepsis. …”
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Defense against adversarial attacks: robust and efficient compressed optimized neural networks
Published 2024“…This training occurs across various compression rates and different segments of a dataset and is ultimately associated with a novel multi-expert architecture. …”
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Ensemble Deep Random Vector Functional Link Neural Network for Regression
Published 2022“…To address this problem, we propose a random skip connection-based edRVFL, which can keep the diversity in the latent space. esc-RVFL is an ensemble scheme that utilizes several edRVFL-RSC models trained on the different folds of the training dataset. …”
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Exploiting the Spatio-Temporal Patterns in IoT Data to Establish a Dynamic Ensemble of Distributed Learners
Published 2018“…Our evaluation experiments using three real-world datasets in the context of the smart city show that our proposed dynamic ensemble strategy leads to an improved error rate of up to 33% compared to the baseline strategy even when using31of the training data. …”
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Toward Adaptive Intrusion Detection Systems for UAVs Using Cyber-Physical Image Analysis
Published 2025“…Despite the growing body of research on intrusion detection systems (IDS) for UAVs, many existing solutions exhibit significant limitations, including a reliance on synthetic datasets and binary classification frameworks. …”
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Self-Supervised Learning Powered by Synthetic Data From Diffusion Models: Application to X-Ray Images
Published 2025“…These findings underscore a significant advancement in the generation of synthetic medical images, providing a viable approach to creating realistic, biomarker-preserving datasets that ensure patient confidentiality and enable diverse applications in medical imaging.…”
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Automated Detection of Colorectal Polyp Utilizing Deep Learning Methods With Explainable AI
Published 2024“…Complementing this, we proposed a novel TR-SE-Net model for segmentation, integrating Squeeze-and-Excite Networks (SE-Net) to elevate performance and real-time processing capabilities. The Kvasir-SEG dataset is utilized for training and testing models, supplemented by external validation CVC-ClinicDB, PolypGen, ETIS-LaribPolypDB, EDD 2020, and BKAI-IGH to confirm their efficacy in processing unseen, real-time data. …”