Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000] by Abdel Khalek, Maya

“…Addition of N-acetyl-cysteine (NAC); being a reactive oxygen species (ROS) scavenger, led to a significant decrease in the cytotoxicity of arginine deprivation to U251 and A172 cells, indicating that ROS generation reversed the cytotoxicity of arginine deprivation to GBM cells. …”
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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia by Shilpa Kuttikrishnan (3520079)

“…<p dir="ltr">Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation of lymphoid precursors with arrested maturation. …”

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) by Roberta Giordo (299595)

“…Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…In addition, we established the antitumor effects of SNG through reactive oxygen species (ROS) production, as inhibiting ROS production prevented the apoptosis-inducing potential of SNG. …”

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... by Mohamed Yassin (4166515)

“…The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. The HOPE trial demonstrated a 51 % improvement in hemoglobin response and a reduction in hemolytic markers in patients treated with voxelotor. …”

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans by Kirti S. Prabhu (4246144)

“…We also found that BTZ exerted its antitumor effects by generating reactive oxygen species (ROS), as blocking ROS production significantly reduced BTZ-induced apoptotic cell death. …”

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back by Lenka Koklesova (18102994)

Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling by Crystal M. Ghantous (14571292)

“…Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production. …”

12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase by Amira Othman (380131)

“…Levels of HETE and inflammatory mediators were examined by LC/MS and Multiplex Immunoassay respectively. ROS generation and NOX2 expression were also measured in mice retinas. 12- and 15- HETE significantly increased permeability and reduced TER and ZO-1expression in REC. …”

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death by Tohme, Sara

“…This involvement of ROS is confirmed with the gradual increase in intracellular ROS levels, reaching a peak at 48 hours after treatment. …”
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Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling by Md Mizanur Rahman (14603354)

“…HFD also significantly increased the number of adipocytes in the bone marrow microenvironment of WT mice as compared to KO mice. …”

Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients by Alessandro Giuseppe Fois (2901365)

“…IPF sera-induced cellular effects were significantly blunted in cells exposed to the NADPH oxidase inhibitor diphenyleneiodonium (DPI) proving the causative role of ROS and suggesting their potential cellular source. …”

Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model by Kobeissy, Firas

“…Finally, reactive oxygen species (ROS) production was significantly accentuated in S+MI group concomitant with a significant increase in NOX-4 protein levels. …”
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The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells by Maram Hasan (6672440)

“…</p> <p>Objective: To assess the protective effect of (MSCs-CM) against MGO-mediated injury of cultured endothelial cells in terms of ROS generation, cell survival, and Nrf2 antioxidant pathway.…”

The anti-cancer effect of series of strained photoactivatable Ru(II) polypyridyl complexes on non-small-cell lung cancer and triple negative breast cancer cells by Fayad, Christelle

“…It also significantly increased Bax/Bcl2 ratio and PERK levels without affecting caspase-3 expression. …”
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STARD 13 in prostate cancer. (c2018) by Saab, Sahar S.

“…Proliferation and migration are known to be regulated by Rho family of GTPases. StarD13 is a GAP for Rho GTPases and has been previously described to be a tumor suppressor in astrocytoma, breast and colorectal cancer. …”
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In Vitro and In Vivo Effects of Lebanese Cannabis Oil Against Acute Myeloid Leukemia (AML) by Lteif, Anthony

“…Western blots analysis further demonstrated that COE triggered a caspase-dependent apoptosis via the extrinsic and intrinsic pathways. In addition, COE significantly inhibited the MAPK pathway. A significant inhibition of ROS production was also observed with COE treatment. …”
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Exploring the Role of Perceived Organizational Injustice and Organizational Identification in the Impact of Discretionary HR Practices on Counterproductive Behaviors: Evidence from... by El Dimassi, Yasmeen

“…It investigates how customized, flexible HR practices are resource-enhancing tools that decrease workplace deviant behaviors. The study uses survey responses from 214 Lebanese employees working in different sectors to fill a significant knowledge gap in HR studies, primarily focusing on Western business settings. …”
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20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway by Stephanie Eid (440990)

“…HG treatment increased ROS production and was associated with alteration in CYPs 4A and 2C11 expression concomitant with alteration in 20-HETE and EETs formation. …”