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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …”
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The Effects of New Public Management on Managers’ Work-Life Balance and Behavior
Published 2020“…The main differing factors included the manner in which NPM was implemented and the negative attitude of the participants when faced with an increasing workload. The key significance of the present study lies in its difference from prior research carried out in other contexts. …”
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Modelling of Concrete Waste Using Life Cycle Assessment & Damage Cost
Published 2019“…Therefore, in this study, a Life Cycle Assessment (LCA) was conducted between the current method of landfilling and its transportation of concrete waste to landfill, and the proposed recycling method. …”
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The Influence of Loneliness and Living Alone on the Quality of Life of the Elderly: Evidence from Europe
Published 2023“…Loneliness among the elderly has become a significant concern, especially post-COVID-19. This thesis explores the relationship between living alone, loneliness, and quality of life (QoL) in elderly Europeans. …”
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The Work Life Balance and Job Satisfaction in Oil and Gas organisations in the UAE context
Published 2010“…The findings show that Work Life Balance (WLB) is significantly and positively correlated with job satisfaction. …”
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Health-related quality of life as a predictor of tuberculosis treatment outcomes in Iraq
Published 2015“…ResultsAfter the 2-month intensive phase, physical well-being, functional well-being, and the overall total scores were significantly increased (p<0.01). Furthermore, at completion of TB treatment, there were significant improvements in the overall HRQL as indicated by the FACIT-TB total score and all subscales, except social and economic well-being and spiritual well-being. …”
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Life Cycle Assessment of Wastewater Treatment Plant Varying Electricity Power Sources
Published 2020“…Wastewater treatment is an essential life process that enhances water quality as population and urbanization are increasing proportionally. …”
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Environmental Sustainability Assessments on Water Distribution Networks: A Life-Cycle Approach
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AI-based remaining useful life prediction and modelling of seawater desalination membranes
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Life cycle assessment on fabrication and characterization techniques for additively manufactured polymers and polymer composites
Published 2023“…<p>Life cycle assessment (LCA) is a powerful tool to evaluate the environmental impacts of any domestic or industrial activity consuming goods and services. …”
