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infection disease » infectious disease (Expand Search), infectious diseases (Expand Search)
decrease » increase (Expand Search)
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Risk of Serious Infections in Patients Treated With Biologic or Targeted‐synthetic Disease Modifying Antirheumatic Drugs in Qatar
Published 2025“…Because of associated immune dysfunction, opportunistic or serious infections (SIs), and latent disease reactivation is frequently reported. …”
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Microbiome profiling of rotavirus infected children suffering from acute gastroenteritis
Published 2022“…Microbial dysbiosis caused by RV infection may significantly influence disease prognosis and the development of other chronic diseases. …”
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Exposure rates to hepatitis C and G virus infections among HIV-infected patients
Published 2004“…The role of HGV in causing significant liver disease is still under dispute…”
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Isolated pulmonary cryptococcosis in a patient with Crohn's disease treated with infliximab: A case report and literature review
Published 2021“…Reactivation of tuberculosis and fungal infections have emerged as significant infective complications of anti-TNF-α therapy. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status
Published 2021“…<p dir="ltr">Paget’s disease of bone (PDB) is characterized by focal increases in disorganized bone remodeling. …”
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T‐cell responses and therapies against SARS‐CoV‐2 infection
Published 2023“…Some studies suggest that COVID-19 could be an immune-related disease, and failure of effective immune responses in initial stages of viral infection could contribute to systemic inflammation and tissue damage, leading to worse disease outcomes. …”