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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Stemming cardiovascular diseases in Qatar
Published 2015“…The importance of diabetes as a risk factor, however, was found to be higher than other countries in the Gulf region and significantly higher than the US.</p><p>“Public health officials should design programmes to improve the prevention, diagnosis, and management of risk factors such as diabetes and hypertension,” says Christos, as well as work on effective awareness campaigns to create a culture of preventive health in Qatar.…”
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The effect of foeniculum vulgare seeds on lipidemia, glycemia & liver enzymes. (c2009)
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TCAD Simulation and Analysis of Selective Buried Oxide MOSFET Dynamic Power
Published 2019“…Increasing power dissipation may lead to decreasing system effciency and lifetime. The BULK metal oxide semiconductor field-effect transistor (MOSFET) has relatively high power dissipation and low frequency response due to its internal capacitances. …”
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Minor Intron Splicing from Basic Science to Disease
Published 2021“…While the majority of introns in humans are U2 type, less than 0.4% are U12 type, also known as minor introns (mi-INTs), and require a specialized spliceosome composed of U11, U12, U4atac, U5, and U6atac snRNPs. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Patient with clinical celiac disease mimicking triple‐negative essential thrombocythemia
Published 2023“…She had positive antibodies for celiac disease, and the diagnosis was confirmed by a small bowel biopsy, which is confirmatory for diagnosing celiac disease in adults. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease
Published 2012“…Our results show that in the patient’s blood, tumor suppressor genes were slightly but significantly higher methylated at several CpG sites, while repeats were slightly less methylated compared to control blood. …”
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Knowledge, attitude, and practice of physicians regarding pain management in patients with Sickle cell disease
Published 2023“…Pain from vaso-occlusive crises (VOCs) is the most common symptom experienced by patients with SCD; thus, pain management constitutes a significant role in this patient population. We hypothesized that physicians with less favorable attitudes toward SCD patients are less likely to follow pain management guidelines. …”
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National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050
Published 2024“…For individuals older than 18 years, overweight was defined as having a BMI of 25 kg/m2 to less than 30 kg/m2 and obesity was defined as a BMI of 30 kg/m2 or higher, and for individuals younger than 18 years definitions were based on International Obesity Task Force criteria. …”
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Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review
Published 2024“…<h3>Background and Aims</h3><p dir="ltr">Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. …”
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Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE)
Published 2020“…ConclusionCAD in the young adult patient with SLE is represented predominately by an African-American population and it is dominated by a hypercoagulable state and a less significant role for diabetes. In the lupus cohort over 55 years, which is predominantly Caucasian, SLE specific factors are less significant.…”
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A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
Published 2019“…However, Jcad<sup>−/−</sup>ApoE<sup>−/−</sup> mice developed significantly less atherosclerosis in the aortic root and the inner curvature of the aortic arch. …”