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Bioinspired design of redox-active ligands for multielectron catalysis
Published 2015“…Both metal- and ligand-centered redox features are observed in organic as well as aqueous solutions over a range of pH values, and comparison with analogs bearing redox-inactive zinc(II) allows for assignments of ligand-based redox events. …”
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2
Coevolving residues distant from the ligand binding site are involved in GAF domain function
Published 2025“…Mutational incorporation into a Bioluminescence Resonance Energy Transfer (BRET)-based biosensors, which detects ligand-induced conformational changes, showed altered GAF domain conformation and increased EC50 for cGMP-induced conformational changes. …”
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3
Prognostic values of the mRNA expression of natural killer receptor ligands and their association with clinicopathological features in breast cancer patients
Published 2018“…Identification of a group of patients with worse prognosis expressing high levels of NK-activating ligands and low levels of NK-inhibitory ligands makes them ideal potential candidates for NK-based immunotherapy to eliminate residual tumor cells, prevent relapse and improve patient survival.…”
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4
Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents
Published 2020“…Photoactivated chemotherapy (PACT) has emerged as a new method for targeted cancer therapy. Strained ruthenium based complexes with octahedral geometry may undergo ligand dissociation once irradiated, forming aquated photoproducts that are greatly cytotoxic compared to their prodrug complex. …”
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5
Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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6
Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
Published 2025“…The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. The HOPE trial demonstrated a 51 % improvement in hemoglobin response and a reduction in hemolytic markers in patients treated with voxelotor. …”
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Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles
Published 2007“…Platinum(II)-based DNA intercalators where the intercalating ligand is 1,10-phenanthroline or a phenanthroline derivative and where the ancillary ligand is either achiral (e.g. ethylenediamine) or chiral (e.g. diaminocyclohexane) show a range of cytotoxicities with a defined structure–activity relationship. …”
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8
Targeting solid tumor cells with novel photosensitive ruthenium-based metal-organic compounds. (c2016)
Published 2016“…The mechanisms by which Ru-based compounds work is still being explored, and other ligands and combination of ligands are also being tested to find the most selective, and potent complex.…”
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masterThesis -
9
Targeting acute myeloid leukemia cells with novel photosensitive ruthenium-based metal-organic compounds. (c2015)
Published 2016“…Of the four free ligands tested (L-I, L-II, L-III and L-IV corresponding to Ru-I, Ru-II, Ru-III and Ru-IV, respectively), significant cytotoxic activity was detected in eight out of nine cell lines, only with L-I and L-II, (IC50 values in the low μM range for L-I and reaching the nM range for L-II). …”
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10
Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension
Published 2023“…On the other hand, neonates of hypertensive mothers administered with methyldopa showed a significant decrease of initial blood glucose reading.…”
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11
Rescue cerclage
Published 2006“…Advanced dilation of 3 cm and/or prolapsed membranes (n = 18) did not decrease the likelihood of reaching 28 weeks. Mean gestational age at delivery for this subset of patients was 30.7 ± 7.2 weeks. …”
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STARD 13 in prostate cancer. (c2018)
Published 2018“…Proliferation and migration are known to be regulated by Rho family of GTPases. StarD13 is a GAP for Rho GTPases and has been previously described to be a tumor suppressor in astrocytoma, breast and colorectal cancer. …”
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13
Food safety knowledge attitude and practices of oncology nurses, in Lebanese hospitals
Published 2023“…Knowledge scores were higher among nurses holding a graduate degree (mean = 85; p < 0.05), and those who attended a training course (mean = 79; p < 0.05). …”
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14
Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained?
Published 2025“…Mean HbA1c significantly decreased from 8.1%preop to 6.77%<sub>year 9</sub>. …”
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15
Sex differences on quality of life and mental health outcomes when using a brief cognitive-behavioral skill building intervention with adolescent Syrian refugees: a secondary analy...
Published 2019“…Among males only, significant decreases in depression and anxiety scores were observed with significant improvement in total QOL.…”
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Food safety knowledge attitude and practices of oncology nurses, in Lebanese hospitals
Published 2023“…Knowledge scores were higher among nurses holding a graduate degree (mean = 85; p < 0.05), and those who attended a training course (mean = 79; p < 0.05). …”
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17
Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries
Published 2023“…These findings have significant implications for labor markets and nationalization policies in the GCC countries.…”
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Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries
Published 2023“…These findings have significant implications for labor markets and nationalization policies in the GCC countries.…”
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Exploring the Role of Perceived Organizational Injustice and Organizational Identification in the Impact of Discretionary HR Practices on Counterproductive Behaviors: Evidence from...
Published 2025“…It investigates how customized, flexible HR practices are resource-enhancing tools that decrease workplace deviant behaviors. The study uses survey responses from 214 Lebanese employees working in different sectors to fill a significant knowledge gap in HR studies, primarily focusing on Western business settings. …”
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masterThesis -
20
Oxygen targets following cardiac arrest: A meta-analysis of randomized controlled trials
Published 2023“…</p> <h3>Conclusions</h3> <p>Conservative oxygen therapy did not decrease mortality, improve neurologic recovery, or decrease ICU LOS as compared to a liberal oxygen regimen. …”