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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Development, Characterization and In Vitro Evaluation of Cannabidiol Loaded Zeolite Nanoparticles
Published 2025“…In addition, Cell Uptake studies demonstrated an increase in CBD internalization and retention by 2.4 folds for the USY loaded zeolite and 1.9 folds for the MCM-41 loaded zeolite when compared to CBD in its free form. …”
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Optimal Planning of Distributed Generators and Shunt Capacitors in Isolated Microgrids With Nonlinear Loads
Published 2020“…The effectiveness of the proposed planning approach has been validated using the PG&E 69-bus system, and the followings are observed: 1) the significance of applying suitable fundamental-power-flow and harmonic-power-flow algorithms for isolated microgrids, and 2) the possibility of avoiding a severe voltage distortion by utilizing an appropriate planning method and only small increase in the cost.…”
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Behavior Of Reinforced Concrete Columns Embedded with PET Bottles Under Concentric Axial Compression
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Effect of Girder Damage on the Structural Behavior of Slab-on-Girder Bridges
Published 2011Get full text
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Comparative Study of the Structural Behaviour of Cast Acrylic & Laminated Glass Under the Impact of Dynamic Loading in Aquatic Applications
Published 2023“…Finally, CA sheets recorded slightly lower deflection values than it was in LG under the increasing effect of hydrostatic pressure (collision depth) and eventually showed almost a constant behavior of stress but significantly lower than those recorded in LG sheets.…”
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Electric Vehicles Charging Station Load Forecasting Integration With Renewable Energy Using Novel Deep EfficientBiLSTMNet
Published 2025“…<p dir="ltr">The exponential increase in the adoption of Electric Vehicles (EVs) presents significant problems to the stability of the power grid. …”
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FEA Investigation of Elastic Buckling for Functionally Graded Material (FGM) Thin Plates with Different Hole Shapes under Uniaxial Loading
Published 2022“…The results show that the increase in the size of the opening and the aspect ratio reduces the critical buckling load of the FGM plate. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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