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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Prediction of evaporation losses in wet cooling towers
Published 2020“…Accurately predicting evaporation losses is significant because water in cooling towers is cooled primarily through the evaporation of a portion of the circulating water, which causes the concentration of dissolved solids and other impurities to increase. …”
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Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.
Published 2025“…It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …”
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Exploring beyond numeric weight loss: The metabolic effects of semaglutide
Published 2025“…</u> It also significantly reduced ad libitum <u>energy intake</u>, decreased hunger, and increased satiety in multiple trials. …”
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Modeling of photovoltaic soiling loss as a function of environmental variables
Published 2017“…Higher WS typically favored more positive daily ΔCI when RH was low, but at higher RH levels (>50%) daily ΔCI was more likely to be negative with increasing WS. In fact, high RH levels were related to negative daily ΔCI only at higher WS levels (>2ms−1); at lower WS levels RH had no significant effect on daily ΔCI. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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The genetic basis and the diagnostic yield of genetic testing related to nonsyndromic hearing loss in Qatar
Published 2024“…The prevalence of hereditary hearing loss increases in consanguineous populations, and the prevalence of hearing loss in Qatar is 5.2%. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Otosyphilis: A rare case of reversible hearing loss in a young man with secondary syphilis
Published 2023“…<h3>Background</h3><p dir="ltr">Over the last decade, it has been noticed a significant increase in the number of cases of syphilis with a concurrent increased number of patients presenting with syphilis-related complications. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
Published 2022“…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …”
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Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Published 2017“…Staining of breast cancer cases for MMP-8 revealed a statistically significant loss of MMP-8 expression in DCIS with invasion versus pure DCIS (<i>p</i> = 0.001).…”
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A Framework for Project Time-Cost Optimization Considering Float Consumption Impact
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Outcomes of drain versus no drain in total knee arthroplasty: a retrospective cohort study
Published 2023“…The aim of this study is to compare the outcomes of patients who received suction drains versus those who did not, focusing on blood loss, blood transfusion need, and length of hospital stay.…”
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Design analysis and experimental validation of a multi‐level inverter for vehicle to home application
Published 2023“…<p dir="ltr">Robust and economic inverting devices are needed with the increasing practice of direct current (DC) sources. …”